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Carcinogenesis Advance Access originally published online on September 11, 2003
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Carcinogenesis, Vol. 24, No. 11, 1853-1854, November 2003
© 2003 Oxford University Press

LETTER TO THE EDITOR

Re: Hengstler,J.G., Bolm-Auorff,U., Faldum,A., Janssen,K., Reifenrath,M., Gotte,W., Jung,D., Mayer-Popken,O., Fuchs,J., Gebhard,S., Bienfait,H.G., Schlink,K., Dietrich,C., Faust,D., Epe,B. and Oesch,F. Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected. Carcinogenesis, 2003, 24, 63–73

M. Kirsch-Volders1 and D. Lison2,3

1 Laboratory of Cell Genetics, Vrije Universiteit, Brussels, Belgium and 2 Unit of Industrial and Environmental Toxicology, Université catholique de Louvain, Brussels, Belgium

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Dear Sir,

In their recent paper Hengstler and collaborators have measured DNA single strand breaks (DNA-SSB) in peripheral mononucleated cells from 78 individuals with alleged occupational exposure to heavy metals, namely cobalt, cadmium and lead and 22 controls (1). They concluded that co-exposure to these metals induced a ‘more than multiplicative effect’ on DNA-SSB and suggested that DNA damage would already be detected from cobalt airborne levels of 4 µg/m3. If correct, this conclusion would be alarming because this level is well below the current exposure limits recommended by different agencies to protect the health of workers, e.g. the American Conference of Governmental Industrial Hygienists (ACGIH) recommends a threshold . . . [Full Text of this Article]


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