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Carcinogenesis Advance Access originally published online on May 9, 2003
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Carcinogenesis, Vol. 24, No. 7, 1281-1282, July 2003
© 2003 Oxford University Press

LETTER TO THE EDITOR

Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma

Jeremy P. Cheadle1,{dagger}, Sunil Dolwani and Julian R. Sampson{dagger}

Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK

1 To whom correspondence should be addressed. Tel: +44 29 20742652; Fax: +44 29 20746551; Email: cheadlejp@cardiff.ac.uk

Abbreviations: BER, base excision repair; 8-oxoG, 8-oxo-7,8-dihydro-2'-deoxyguanosine

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In a recent Commentary in Carcinogenesis, Hazra and colleagues described the discovery of a new family of mammalian enzymes for the repair of oxidatively damaged DNA and suggested that ‘the multiplicity of DNA glycosylases with overlapping substrate ranges could explain why ... deficiency of the base . . . [Full Text of this Article]


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