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Carcinogenesis, Vol. 23, No. 6, 1089, June 2002
© 2002 Oxford University Press

RESPONSE TO LETTER TO THE EDITOR

Cancer, genes and gender

Aage Haugen

Department of Toxicology, National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway

I appreciate the comments of Dr Meisel. In the letter, Dr Meisel has not expressed any concern about my commentary but argues that myeloperoxidase (MPO) and other enzymes involved in the metabolism of tobacco carcinogens regulated by hormones may contribute to sex-specific lung cancer risk. I share his view. We have demonstrated higher CYP1A1 expression levels in normal lung from females. There is also some animal data indicating a sex-difference in the abundance of detoxification enzymes (1).

Reference

  1. Singhal,S.S., Saxena,M., Ahmad,H. and Awathi,Y.C. (1992) Glutathione S-transferases of mouse liver: sex related differences in the expression of various isozymes. Biochem. Biophys. Acta, 1116, 622–627.
Received March 21, 2002; accepted April 2, 2002.


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This Article
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