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Retraction for Alyaqoub et al., Carcinogenesis 27 (12) 2442-2447.
Retraction for Alyaqoub et al., Carcinogenesis 28 (1) 124-129.
Carcinogenesis 2007 28(11):2426; doi:10.1093/carcin/bgm230
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© Oxford University Press 2007. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)

Fadel S. Alyaqoub, Lianhui Tao, Paula M. Kramer, Vernon E. Steele, Ronald A. Lubet, William T. Gunning and Michael A. Pereira

This article has already been published in Carcinogenesis with the DOI BGL088 and therefore must be withdrawn. Oxford University Press hereby retract the latter paper, BGL136, and discourage any citation of it.

For further reference the abstract is printed below.

Abstract

Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for modulation of DNA methylation in tumors. Lung tumors were induced by vinyl carbamate in female Strain A mice. One week later, mice received 60 or 100 mg/kg R115777 by oral gavage and 5 days/week, 0.8 or 1.6 mg/kg of budesonide in their diet, or their combined treatment until killed at 20, 28 and 36 weeks after administering the vinyl carbamate. Other mice were administered the drugs for 2 weeks before killing at 20 weeks. At Week 20, the rank order for prevention of lung tumors was the combined treatment > budesonide > R115777. At later killings, R115777 was no longer effective, whereas budesonide and the combinations continued to prevent tumors, albeit at a reduced efficacy. DNA hypomethylation in lung tumors was prevented by treatment with R115777, budesonide and the combinations. When administered starting at Week 18 to tumor-bearing mice, the drugs reversed DNA hypomethylation in the tumors. In summary, combined treatment with budesonide and R115777 produced the following results: (i) it was more efficacious in preventing lung tumors than the individual drugs; and (ii) it prevented and reversed DNA hypomethylation in lung tumors. These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate endpoint biomarker for prevention.


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This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
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Right arrow Email this article to a friend
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Right arrow Similar articles in PubMed
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ISI Web of Science (1)
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Google Scholar
Right arrow Articles by Alyaqoub, F. S.
Right arrow Articles by Pereira, M. A.
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PubMed
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Right arrow Articles by Alyaqoub, F. S.
Right arrow Articles by Pereira, M. A.
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