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© 1991 Oxford University Press

research-article

Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), in cigarette smoke condensate

Shigeo Manabe, Kazuhiko Tohyama 1, Osamu Wada and Takemasa Aramaki 2

Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
1Department of Application Technology, Techno Research Laboratory, Hitachi Instrument Engineerrng Co. Ltd 882 Ichige, Katsuta-shi, Ibaraki 312, Japan
2The Ohmiya Kyoritsu Hospital Katayanagi 1550, Ohmiya, Saitama 330, Japan

A carcinogenic heterocycic amine, 2-amlno-1-methyl-6-phenylimidazo[4,5-b] (PhIP), was measured in condensate of cigarette mainstream smoke by HPLC. PhIP was detected in all brands of filter-tipped cigarettes analyzed. The mean level of PhIP in the cigarette mainstream smoke was 16.4 ng/cig.


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