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© 1991 Oxford University Press

other

Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide

Kohfuku Kohda, Yutaka Kawazoe, Yasushi Minoura 1 and Mariko Tada 1

Faculty of Pharmaceutical Sciences, Nagoya City University Tanabedori, Mizuho-ku, Nagoya 467, Japan
1Laboratory of Biochemistry, Aichi Cancer Center Research Institute Kanokoden, Chikusa-ku, Nagoya 464, Japan

A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, was separated and identified after RNA was treated with activated 4-hydroxyaminoquinoline 1-oxide. This is the first report of a 7-arylaminated guanine adduct produced by arylaminating carcinogens.


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 Toxicol SciHome page
Y. Arima, C. Nishigori, T. Takeuchi, S. Oka, K. Morimoto, A. Utani, and Y. Miyachi
4-Nitroquinoline 1-Oxide Forms 8-Hydroxydeoxyguanosine in Human Fibroblasts through Reactive Oxygen Species
Toxicol. Sci., June 1, 2006; 91(2): 382 - 392.
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