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© 1993 Oxford University Press

other

No allelic loss at the p53 locus in 1,2-dimethylhydrazine-induced mouse colon tumors: PCR-SSCP analysis with sequence-tagged microsatellite site primers

Mieko Okamoto, Hiroshi Ohtsu 1, Michiko Miyaki 2 and Hiromichi Yonekawa

Departments of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science 3–18–22 Honkomagome, Bunkyo-ku, Tokyo 113
1Department of Physiology Pathology, National Institute of Radiological Sciences 4–9–1 Anagawa, Inage-ku, Chiba, Japan
2Biochemistry, The Tokyo Metropolitan Institute of Medical Science 3–18–22 Honkomagome, Bunkyo-ku, Tokyo 113
Pathology, National Institute of Radiological Sciences 4–9–1 Anagawa, Inage-ku, Chiba, Japan

We examined allelic loss in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice, using sequence-tagged microsatellite site (STMS) primers derived from the chromosomal region closely linked to the p53 locus. Polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis of 155 colonic tumors with two STMS markers revealed that no genetic alterations had occurred in these tumors, except for one case where one of the markers detected an increase of one CA repeat unit in one allele. No allelic loss at the loci closely linked to the p53 locus strongly suggests that allelic loss at the p53 locus is not involved in DMH-induced colon carcinogenesis in mice.


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