Carcinogenesis, Vol 18, 185-192, Copyright © 1997 by Oxford University Press
T Ichinose, Y Yajima, M Nagashima, S Takenoshita, Y Nagamachi and M Sagai
In order to clarify the involvement of oxygen radicals in lung
carcinogenesis induced by diesel exhaust particles (DEP), the relationship
between lung tumour response and formation of 8- hydroxydeoxyguanosine
(8-OHdG) in lung DNA was examined. The role of high dietary fat and
beta-carotene on these responses was also studied. Mice were
intratracheally injected with 0.05, 0.1 and 0.2 mg of DEP per animal once
weekly for 10 weeks. After 12 months, the lung tumour incidence in mice
treated with 0.05 mg and 0.1 mg showed similar increases (30% and 31%), but
was decreased to 24% at 0.2 mg. High dietary fat enhanced the incidence of
both benign and malignant tumours. beta-carotene partially prevented the
tumour development. After the 10 weekly treatments of DEP, inflammatory
reaction was observed in the respiratory tract and alveoli. The formation
of 8-OHdG in lung DNA from mice treated with DEP showed a dose dependent
increase. 8-OHdG formation was enhanced by high dietary fat and partially
reduced by beta-carotene. Formation of 8-OHdG was significantly correlated
with the lung tumour incidence except at 0.2 mg. These results suggest that
the induction of oxidative DNA damage may be an important factor in the
initiation of DEP-induced lung carcinogenesis, and that beta-carotene and
high dietary fat may play a role in the regulation of tumour development
via modulation of the formation of 8-OHdG.
ARTICLES
Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles
Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K.-i. Inoue, H. Takano, E. Koike, R. Yanagisawa, M. Sakurai, S. Tasaka, A. Ishizaka, and A. Shimada Effects of Pulmonary Exposure to Carbon Nanotubes on Lung and Systemic Inflammation with Coagulatory Disturbance Induced by Lipopolysaccharide in Mice Experimental Biology and Medicine, December 1, 2008; 233(12): 1583 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Devaraj, S. Mathur, A. Basu, H. H. Aung, V. T. Vasu, S. Meyers, and I. Jialal A Dose-Response Study on the Effects of Purified Lycopene Supplementation on Biomarkers of Oxidative Stress J. Am. Coll. Nutr., April 1, 2008; 27(2): 267 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Li, S. Taneda, A. K. Suzuki, C. Furuta, G. Watanabe, and K. Taya Effects of 3-Methyl-4-Nitrophenol in Diesel Exhaust Particles on the Regulation of Testicular Function in Immature Male Rats J Androl, March 1, 2007; 28(2): 252 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Li, S. Takahashi, S. Taneda, C. Furuta, G. Watanabe, A. K Suzuki, and K. Taya Impairment of testicular function in adult male Japanese quail (Coturnix japonica) after a single administration of 3-methyl-4-nitrophenol in diesel exhaust particles. J. Endocrinol., June 1, 2006; 189(3): 555 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li and A. E. Nel The cellular impacts of diesel exhaust particles: beyond inflammation and death. Eur. Respir. J., April 1, 2006; 27(4): 667 - 668. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and K. Husgafvel-Pursiainen Air pollution and cancer: biomarker studies in human populations Carcinogenesis, November 1, 2005; 26(11): 1846 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sorensen, R. P.F. Schins, O. Hertel, and S. Loft Transition Metals in Personal Samples of PM2.5 and Oxidative Stress in Human Volunteers Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1340 - 1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Avogbe, L. Ayi-Fanou, H. Autrup, S. Loft, B. Fayomi, A. Sanni, P. Vinzents, and P. Moller Ultrafine particulate matter and high-level benzene urban air pollution in relation to oxidative DNA damage Carcinogenesis, March 1, 2005; 26(3): 613 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. W. Cheng, W. W. Lee, C. H. Li, C. C. Lee, and J. J. Kang Genotoxicity of Motorcycle Exhaust Particles In Vivo and In Vitro Toxicol. Sci., September 1, 2004; 81(1): 103 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Furuta, A. K. Suzuki, S. Taneda, K. Kamata, H. Hayashi, Y. Mori, C. Li, G. Watanabe, and K. Taya Estrogenic Activities of Nitrophenols in Diesel Exhaust Particles Biol Reprod, May 1, 2004; 70(5): 1527 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Risom, M. Dybdahl, J. Bornholdt, U. Vogel, H. Wallin, P. Moller, and S. Loft Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation Carcinogenesis, November 1, 2003; 24(11): 1847 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dybdahl, L. Risom, P. Moller, H. Autrup, H. Wallin, U. Vogel, J. Bornholdt, B. Daneshvar, L. O. Dragsted, A. Weimann, et al. DNA adduct formation and oxidative stress in colon and liver of Big Blue(R) rats after dietary exposure to diesel particles Carcinogenesis, November 1, 2003; 24(11): 1759 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sorensen, H. Autrup, O. Hertel, H. Wallin, L. E. Knudsen, and S. Loft Personal Exposure to PM2.5 and Biomarkers of DNA Damage Cancer Epidemiol. Biomarkers Prev., March 1, 2003; 12(3): 191 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Wong, A. S. Bernards, J. K. Miller, and J. A. Wirz A Dimeric Mechanism for Contextual Target Recognition by MutY Glycosylase J. Biol. Chem., January 17, 2003; 278(4): 2411 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Kondraganti, W. Jiang, and B. Moorthy Differential Regulation of Expression of Hepatic and Pulmonary Cytochrome P4501A Enzymes by 3-Methylcholanthrene in Mice Lacking the CYP1A2 Gene J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 945 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, M. Stacewicz-Sapuntzakis, C. Duncan, R. Sharifi, L. Ghosh, R. v. Breemen, D. Ashton, and P. E. Bowen Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention J Natl Cancer Inst, December 19, 2001; 93(24): 1872 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Gottschling, R. R. Maronpot, J. R. Hailey, S. Peddada, C. R. Moomaw, J. E. Klaunig, and A. Nyska The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats Toxicol. Sci., November 1, 2001; 64(1): 28 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Moorthy Persistent Expression of 3-Methylcholanthrene-Inducible Cytochromes P4501A in Rat Hepatic and Extrahepatic Tissues J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 313 - 322. [Abstract] [Full Text]
|
|
|
|
|
|
H. Sato, H. Sone, M. Sagai, K. T. Suzuki, and Y. Aoki Increase in mutation frequency in lung of Big Blue(R) rat by exposure to diesel exhaust Carcinogenesis, April 1, 2000; 21(4): 653 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Hiura, M. P. Kaszubowski, N. Li, and A. E. Nel Chemicals in Diesel Exhaust Particles Generate Reactive Oxygen Radicals and Induce Apoptosis in Macrophages J. Immunol., November 15, 1999; 163(10): 5582 - 5591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yoshino and M. Sagai Enhancement of Collagen-Induced Arthritis in Mice by Diesel Exhaust Particles J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 524 - 529. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Tsurudome, T. Hirano, H. Yamato, I. Tanaka, M. Sagai, H. Hirano, N. Nagata, H. Itoh, and H. Kasai Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles Carcinogenesis, August 1, 1999; 20(8): 1573 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Beckman and B. N. Ames Oxidative Decay of DNA J. Biol. Chem., August 8, 1997; 272(32): 19633 - 19636. [Full Text] [PDF]
|
|