Carcinogenesis, Vol 18, 59-81, Copyright © 1997 by Oxford University Press
JW Grisham
The morphology of hepatocellular carcinoma is similar among mice, rats and
humans, and the cellular pathogenesis shows features that are both similar
and divergent among these species. However, major elements of etiology,
molecular pathogenesis, and natural history differ between humans and
rodents. As a reflection of these species-determined differences, rodents
appear to be neither highly sensitive nor highly specific surrogates for
detecting agents that are potential causes of hepatocellular cancer in
humans. Results of tests of chemical carcinogenicity in rodents are likely
to include a significant number of both false-positive and false-negative
risks for humans.
REVIEW LITERATURE
Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA.
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