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Carcinogenesis, Vol 18, 641-644, Copyright © 1997 by Oxford University Press


ARTICLES

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

LW Harries, MJ Stubbins, D Forman, GC Howard and CR Wolf
Imperial Cancer Research Fund, Ninewells Hospital and Medical School, Dundee, UK.

Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus, which differ by a single base pair (A-G) substitution at nucleotide 313 of the GSTP1 cDNA. This results in an amino acid substitution which alters the function of the enzyme. In this study, a novel PCR assay has been developed which demonstrates that these two variant cDNAs represent distinct GSTP1 alleles (GSTP1a and GSTP1b). In a study of individuals with different forms of cancer, the GSTP1b allele is found to be strongly associated with bladder cancer and testicular cancer. In controls 6.5% of individuals were homozygous for the GSTP1b allele. In bladder cancer cases, this rose to 19.7% [n = 71, odds ratio 3.6 (1.4-9.2), P = 0.006] and in testicular cancer to 18.7% [n = 155, odds ratio 3.3 (1.5-7.7), P = 0.002]. In addition, in prostate cancer a highly significant decrease in the frequency of the GSTP1a homozygotes was observed [control 51.0% versus 27.8% cancer cases, n = 36, odds ratio 0.4 (0.02-3.3), P = 0.008]. Increases in the frequency of GSTP1b homozygotes was also observed in lung cancer and chronic obstructive pulmonary disease. However, these were not statistically significant. No change in breast or colon cancer allele frequencies was observed.
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JNCI J Natl Cancer InstHome page
J. Stoehlmacher, D. J. Park, W. Zhang, S. Groshen, D. D. Tsao-Wei, M. C. Yu, and H.-J. Lenz
Association Between Glutathione S-Transferase P1, T1, and M1 Genetic Polymorphism and Survival of Patients With Metastatic Colorectal Cancer
J Natl Cancer Inst, June 19, 2002; 94(12): 936 - 942.
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C. Jeronimo, G. Varzim, R. Henrique, J. Oliveira, M. J. Bento, C. Silva, C. Lopes, and D. Sidransky
I105V Polymorphism and Promoter Methylation of the GSTP1 Gene in Prostate Adenocarcinoma
Cancer Epidemiol. Biomarkers Prev., May 1, 2002; 11(5): 445 - 450.
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M M de Jong, I M Nolte, G J te Meerman, W T A van der Graaf, J C Oosterwijk, J H Kleibeuker, M Schaapveld, and E G E de Vries
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility
J. Med. Genet., April 1, 2002; 39(4): 225 - 242.
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M. Zhao, R. Lewis, D. R. Gustafson, W.-Q. Wen, J. R. Cerhan, and W. Zheng
No Apparent Association of GSTP1 A313G Polymorphism with Breast Cancer Risk among Postmenopausal Iowa Women
Cancer Epidemiol. Biomarkers Prev., December 1, 2001; 10(12): 1301 - 1302.
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K. Gudmundsdottir, L. Tryggvadottir, and J. E. Eyfjord
GSTM1, GSTT1, and GSTP1 Genotypes in Relation to Breast Cancer Risk and Frequency of Mutations in the p53 Gene
Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1169 - 1173.
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J Zhang, M Ichiba, K Hara, S Zhang, T Hanaoka, G Pan, Y Yamano, K Takahashi, and K Tomokuni
Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes
Occup. Environ. Med., November 1, 2001; 58(11): 716 - 721.
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Proc. Natl. Acad. Sci. USAHome page
J. M. Allan, C. P. Wild, S. Rollinson, E. V. Willett, A. V. Moorman, G. J. Dovey, P. L. Roddam, E. Roman, R. A. Cartwright, and G. J. Morgan
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia
PNAS, September 5, 2001; (2001) 191211198.
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J. D. Brooks, V. G. Paton, and G. Vidanes
Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane
Cancer Epidemiol. Biomarkers Prev., September 1, 2001; 10(9): 949 - 954.
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CarcinogenesisHome page
A. Loktionov, M. A. Watson, M. Gunter, W. S.L. Stebbings, C. T.M. Speakman, and S. A. Bingham
Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor
Carcinogenesis, July 1, 2001; 22(7): 1053 - 1060.
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R. A. Sharma, H. R. McLelland, K. A. Hill, C. R. Ireson, S. A. Euden, M. M. Manson, M. Pirmohamed, L. J. Marnett, A. J. Gescher, and W. P. Steward
Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer
Clin. Cancer Res., July 1, 2001; 7(7): 1894 - 1900.
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Y. Ko, J. Abel, V. Harth, P. Brode, C. Antony, S. Donat, H.-P. Fischer, M. E. Ortiz-Pallardo, R. Thier, A. Sachinidis, et al.
Association of CYP1B1 Codon 432 Mutant Allele in Head and Neck Squamous Cell Cancer Is Reflected by Somatic Mutations of p53 in Tumor Tissue
Cancer Res., June 1, 2001; 61(11): 4398 - 4404.
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R. Singal, J. van Wert, and M. Bashambu
Cytosine Methylation Represses Glutathione S-Transferase P1 (GSTP1) Gene Expression in Human Prostate Cancer Cells
Cancer Res., June 1, 2001; 61(12): 4820 - 4826.
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CarcinogenesisHome page
H.-M. Nan, H. Kim, H.-S. Lim, J. K. Choi, T. Kawamoto, J.-W. Kang, C.-H. Lee, Y.-D. Kim, and E. H. Kwon
Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations
Carcinogenesis, May 1, 2001; 22(5): 787 - 793.
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K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, H. Vainio, M. Uusitupa, and A. Hirvonen
Glutathione S-Transferase M1, M3, P1, and T1 Genetic Polymorphisms and Susceptibility to Breast Cancer
Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 229 - 236.
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CarcinogenesisHome page
A. B. Spurdle, P. M. Webb, D. M. Purdie, X. Chen, A. Green, and G. Chenevix-Trench
Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype
Carcinogenesis, January 1, 2001; 22(1): 67 - 72.
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T. F. Shepard, E. A. Platz, P. W. Kantoff, W. G. Nelson, W. B. Isaacs, D. Freije, P. G. Febbo, M. J. Stampfer, and E. Giovannucci
No Association between the I105V Polymorphism of the Glutathione S-Transferase P1 Gene (GSTP1) and Prostate Cancer Risk: A Prospective Study
Cancer Epidemiol. Biomarkers Prev., November 1, 2000; 9(11): 1267 - 1268.
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P. V. Nerurkar, L. Okinaka, C. Aoki, A. Seifried, A. Lum-Jones, L. R. Wilkens, and L. Le Marchand
CYP1A1, GSTM1, and GSTP1 Genetic Polymorphisms and Urinary 1-Hydroxypyrene Excretion in Non-Occupationally Exposed Individuals
Cancer Epidemiol. Biomarkers Prev., October 1, 2000; 9(10): 1119 - 1122.
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C. Sweeney, G. Y. McClure, M. Y. Fares, A. Stone, B. F. Coles, P. A. Thompson, S. Korourian, L. F. Hutchins, F. F. Kadlubar, and C. B. Ambrosone
Association between Survival after Treatment for Breast Cancer and Glutathione S-Transferase P1 Ile105Val Polymorphism
Cancer Res., October 1, 2000; 60(20): 5621 - 5624.
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J Natl Cancer Inst MonogrHome page
R. Raftogianis, C. Creveling, R. Weinshilboum, and J. Weisz
Chapter 6: Estrogen Metabolism by Conjugation
J Natl Cancer Inst Monographs, July 1, 2000; 2000(27): 113 - 124.
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R Montironi, R Mazzucchelli, D Stramazzotti, R Pomante, D Thompson, and P H Bartels
Expression of {pi}-class glutathione S-transferase: two populations of high grade prostatic intraepithelial neoplasia with different relations to carcinoma
Mol. Pathol., June 1, 2000; 53(3): 122 - 128.
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ThoraxHome page
F. RODRIGUEZ-FRIAS, C. GONZALEZ, X. COSTA, F. CAMPOS, M. COTRINA, R. JARDI, M. MIRAVITLLES, R. VIDAL;, T. ISHII, S. TERAMOTO, et al.
Screening for polymorphisms in exon 5 of the glutathione S-transferase Pl gene
Thorax, June 1, 2000; 55(6): 535b - 535.
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A. A. FRYER, A. BIANCO, M. HEPPLE, P. W. JONES, R. C. STRANGE, and M. A. SPITERI
Polymorphism at the Glutathione S-transferase GSTP1 Locus . A New Marker for Bronchial Hyperresponsiveness and Asthma
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1437 - 1442.
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C. Sweeney, D. C. Farrow, S. M. Schwartz, D. L. Eaton, H. Checkoway, and T. L. Vaughan
Glutathione S-Transferase M1, T1, and P1 Polymorphisms as Risk Factors for Renal Cell Carcinoma: A Case-Control Study
Cancer Epidemiol. Biomarkers Prev., April 1, 2000; 9(4): 449 - 454.
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M. H. WILSON, P. J. GRANT, L. J. HARDIE, and C. P. WILD
Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction
FASEB J, April 1, 2000; 14(5): 791 - 796.
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E. L. Crawford, S. A. Khuder, S. J. Durham, M. Frampton, M. Utell, W. G. Thilly, D. A. Weaver, W. J. Ferencak, C. A. Jennings, J. R. Hammersley, et al.
Normal Bronchial Epithelial Cell Expression of Glutathione Transferase P1, Glutathione Transferase M3, and Glutathione Peroxidase Is Low in Subjects with Bronchogenic Carcinoma
Cancer Res., March 1, 2000; 60(6): 1609 - 1618.
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BloodHome page
M. Stanulla, M. Schrappe, A. M. Brechlin, M. Zimmermann, and K. Welte
Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study
Blood, February 15, 2000; 95(4): 1222 - 1228.
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NeurologyHome page
C. L. A. Mann, M. B. Davies, M. D. Boggild, J. Alldersea, A. A. Fryer, P. W. Jones, C. Ko Ko, C. Young, R. C. Strange, and C. P. Hawkins
Glutathione S-transferase polymorphisms in MS: Their relationship to disability
Neurology, February 8, 2000; 54(3): 552 - 552.
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R. M. Whyatt, F. P. Perera, W. Jedrychowski, R. M. Santella, S. Garte, and D. A. Bell
Association between Polycyclic Aromatic Hydrocarbon-DNA Adduct Levels in Maternal and Newborn White Blood Cells and Glutathione S-Transferase P1 and CYP1A1 Polymorphisms
Cancer Epidemiol. Biomarkers Prev., February 1, 2000; 9(2): 207 - 212.
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CarcinogenesisHome page
S. Rollinson, P. Roddam, E. Kane, E. Roman, R. Cartwright, A. Jack, and G. J. Morgan
Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia
Carcinogenesis, January 1, 2000; 21(1): 43 - 47.
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A. M. Dunning, C. S. Healey, P. D. P. Pharoah, M. D. Teare, B. A. J. Ponder, and D. F. Easton
A Systematic Review Of Genetic Polymorphisms and Breast Cancer Risk
Cancer Epidemiol. Biomarkers Prev., October 1, 1999; 8(10): 843 - 854.
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CarcinogenesisHome page
S. Ozawa, B. Schoket, L.P. McDaniel, Y.-M. Tang, C. B. Ambrosone, S. Kostic, I. Vincze, and F. F. Kadlubar
Analyses of bronchial bulky DNA adduct levels and CYP2C9, GSTP1 and NQO1 genotypes in a Hungarian study population with pulmonary diseases
Carcinogenesis, June 1, 1999; 20(6): 991 - 995.
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S. Longuemaux, C. Delomenie, C. Gallou, A. Mejean, M. Vincent-Viry, R. Bouvier, D. Droz, R. Krishnamoorthy, M.-M. Galteau, C. Junien, et al.
Candidate Genetic Modifiers of Individual Susceptibility to Renal Cell Carcinoma: A Study of Polymorphic Human Xenobiotic-metabolizing Enzymes
Cancer Res., June 1, 1999; 59(12): 2903 - 2908.
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X. Hu, C. Herzog, P. Zimniak, and S. V. Singh
Differential Protection against Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA Damage in HepG2 Cells Stably Transfected with Allelic Variants of {{pi}} Class Human Glutathione S-Transferase
Cancer Res., May 1, 1999; 59(10): 2358 - 2362.
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Cancer Epidemiol. Biomarkers Prev.Home page
T. R. Rebbeck, A. H. Walker, J. M. Jaffe, D. L. White, A. J. Wein, and S. B. Malkowicz
Glutathione S-Transferase-{micro} (GSTM1) and -{theta} (GSTT1) Genotypes in the Etiology of Prostate Cancer1
Cancer Epidemiol. Biomarkers Prev., April 1, 1999; 8(4): 283 - 287.
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M. Welfare, A. M. Adeokun, M. F. Bassendine, and A. K. Daly
Polymorphisms in GSTP1, GSTM1, and GSTT1 and Susceptibility to Colorectal Cancer1
Cancer Epidemiol. Biomarkers Prev., April 1, 1999; 8(4): 289 - 292.
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CarcinogenesisHome page
C. Chen and W. Nirunsuksiri
Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture
Carcinogenesis, April 1, 1999; 20(4): 699 - 703.
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Ann Rheum DisHome page
D. L Mattey, A. B Hassell, M. Plant, P. T Dawes, W. R Ollier, P. W Jones, A. A Fryer, J. E Alldersea, and R. C Strange
Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope
Ann Rheum Dis, March 1, 1999; 58(3): 164 - 168.
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E. M. M. van Lieshout, H. M. J. Roelofs, S. Dekker, C. J. J. Mulder, T. Wobbes, J. B. M. J. Jansen, and W. H. M. Peters
Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett's Esophagus and Esophageal Carcinoma
Cancer Res., February 1, 1999; 59(3): 586 - 589.
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W. R. Fields, C. S. Morrow, A. J. Doss, K. Sundberg, B. Jernström, and A. J. Townsend
Overexpression of Stably Transfected Human Glutathione S-Transferase P1-1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells
Mol. Pharmacol., August 1, 1998; 54(2): 298 - 304.
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Proc. Natl. Acad. Sci. USAHome page
C. J. Henderson, A. G. Smith, J. Ure, K. Brown, E. J. Bacon, and C. R. Wolf
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
PNAS, April 28, 1998; 95(9): 5275 - 5280.
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Proc. Natl. Acad. Sci. USAHome page
J. M. Allan, C. P. Wild, S. Rollinson, E. V. Willett, A. V. Moorman, G. J. Dovey, P. L. Roddam, E. Roman, R. A. Cartwright, and G. J. Morgan
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia
PNAS, September 25, 2001; 98(20): 11592 - 11597.
[Abstract] [Full Text] [PDF]



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