Carcinogenesis, Vol 18, 641-644, Copyright © 1997 by Oxford University Press
LW Harries, MJ Stubbins, D Forman, GC Howard and CR Wolf
Two variant glutathione S-transferase cDNAs have been described at the
GSTP1 locus, which differ by a single base pair (A-G) substitution at
nucleotide 313 of the GSTP1 cDNA. This results in an amino acid
substitution which alters the function of the enzyme. In this study, a
novel PCR assay has been developed which demonstrates that these two
variant cDNAs represent distinct GSTP1 alleles (GSTP1a and GSTP1b). In a
study of individuals with different forms of cancer, the GSTP1b allele is
found to be strongly associated with bladder cancer and testicular cancer.
In controls 6.5% of individuals were homozygous for the GSTP1b allele. In
bladder cancer cases, this rose to 19.7% [n = 71, odds ratio 3.6 (1.4-9.2),
P = 0.006] and in testicular cancer to 18.7% [n = 155, odds ratio 3.3
(1.5-7.7), P = 0.002]. In addition, in prostate cancer a highly significant
decrease in the frequency of the GSTP1a homozygotes was observed [control
51.0% versus 27.8% cancer cases, n = 36, odds ratio 0.4 (0.02-3.3), P =
0.008]. Increases in the frequency of GSTP1b homozygotes was also observed
in lung cancer and chronic obstructive pulmonary disease. However, these
were not statistically significant. No change in breast or colon cancer
allele frequencies was observed.
ARTICLES
Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer
Imperial Cancer Research Fund, Ninewells Hospital and Medical School, Dundee, UK.
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|
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|
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|
|
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|
|
|
|
 |
|
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|
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|
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|
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|
|
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|
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|
|
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|
|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. M. Knaapen, H. B. Ketelslegers, R. W.H. Gottschalk, R. G.J.H. Janssen, A. D.C. Paulussen, H. J.M. Smeets, R. W.L. Godschalk, F. J. Van Schooten, J. C.S. Kleinjans, and J. H.M. Van Delft Simultaneous Genotyping of Nine Polymorphisms in Xenobiotic-Metabolizing Enzymes by Multiplex PCR Amplification and Single Base Extension Clin. Chem., September 1, 2004; 50(9): 1664 - 1668. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 E. L. Abel, S. M. Opp, C. L. M. J. Verlinde, T. K. Bammler, and D. L. Eaton Characterization of Atrazine Biotransformation by Human and Murine Glutathione S-Transferases Toxicol. Sci., August 1, 2004; 80(2): 230 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Burim, R. Canalle, A. d. L. C. Martinelli, and C. S. Takahashi Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics Mutagenesis, July 1, 2004; 19(4): 291 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
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|
|
|
|
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|
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 |
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 S. Kishi, W. Yang, B. Boureau, S. Morand, S. Das, P. Chen, E. H. Cook, G. L. Rosner, E. Schuetz, C.-H. Pui, et al. Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia Blood, January 1, 2004; 103(1): 67 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 D J de Jong, E M J van der Logt, A van Schaik, H M J Roelofs, W H M Peters, and T H J Naber Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase Gut, April 1, 2003; 52(4): 547 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
Y.-J. Cheng, Y.-C. Chien, A. Hildesheim, M.-M. Hsu, I-H. Chen, J. Chuang, J. Chang, Y. D. Ma, C.-T. Luo, W.-L. Hsu, et al. No Association Between Genetic Polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and Nasopharyngeal Carcinoma in Taiwan Cancer Epidemiol. Biomarkers Prev., February 1, 2003; 12(2): 179 - 180. [Full Text] [PDF]
|
|
|
|
|
|
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|
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|
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|
|
|
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|
|
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|
|
|
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 |
|
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|
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K. Gudmundsdottir, L. Tryggvadottir, and J. E. Eyfjord GSTM1, GSTT1, and GSTP1 Genotypes in Relation to Breast Cancer Risk and Frequency of Mutations in the p53 Gene Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1169 - 1173. [Abstract] [Full Text] [PDF]
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 J Zhang, M Ichiba, K Hara, S Zhang, T Hanaoka, G Pan, Y Yamano, K Takahashi, and K Tomokuni Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes Occup. Environ. Med., November 1, 2001; 58(11): 716 - 721. [Abstract] [Full Text]
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 J. M. Allan, C. P. Wild, S. Rollinson, E. V. Willett, A. V. Moorman, G. J. Dovey, P. L. Roddam, E. Roman, R. A. Cartwright, and G. J. Morgan Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia PNAS, September 5, 2001; (2001) 191211198. [Abstract] [Full Text] [PDF]
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J. D. Brooks, V. G. Paton, and G. Vidanes Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane Cancer Epidemiol. Biomarkers Prev., September 1, 2001; 10(9): 949 - 954. [Abstract] [Full Text] [PDF]
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A. Loktionov, M. A. Watson, M. Gunter, W. S.L. Stebbings, C. T.M. Speakman, and S. A. Bingham Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor Carcinogenesis, July 1, 2001; 22(7): 1053 - 1060. [Abstract] [Full Text] [PDF]
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R. A. Sharma, H. R. McLelland, K. A. Hill, C. R. Ireson, S. A. Euden, M. M. Manson, M. Pirmohamed, L. J. Marnett, A. J. Gescher, and W. P. Steward Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer Clin. Cancer Res., July 1, 2001; 7(7): 1894 - 1900. [Abstract] [Full Text] [PDF]
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Y. Ko, J. Abel, V. Harth, P. Brode, C. Antony, S. Donat, H.-P. Fischer, M. E. Ortiz-Pallardo, R. Thier, A. Sachinidis, et al. Association of CYP1B1 Codon 432 Mutant Allele in Head and Neck Squamous Cell Cancer Is Reflected by Somatic Mutations of p53 in Tumor Tissue Cancer Res., June 1, 2001; 61(11): 4398 - 4404. [Abstract] [Full Text] [PDF]
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R. Singal, J. van Wert, and M. Bashambu Cytosine Methylation Represses Glutathione S-Transferase P1 (GSTP1) Gene Expression in Human Prostate Cancer Cells Cancer Res., June 1, 2001; 61(12): 4820 - 4826. [Abstract] [Full Text] [PDF]
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H.-M. Nan, H. Kim, H.-S. Lim, J. K. Choi, T. Kawamoto, J.-W. Kang, C.-H. Lee, Y.-D. Kim, and E. H. Kwon Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations Carcinogenesis, May 1, 2001; 22(5): 787 - 793. [Abstract] [Full Text] [PDF]
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K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, H. Vainio, M. Uusitupa, and A. Hirvonen Glutathione S-Transferase M1, M3, P1, and T1 Genetic Polymorphisms and Susceptibility to Breast Cancer Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 229 - 236. [Abstract] [Full Text]
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A. B. Spurdle, P. M. Webb, D. M. Purdie, X. Chen, A. Green, and G. Chenevix-Trench Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype Carcinogenesis, January 1, 2001; 22(1): 67 - 72. [Abstract] [Full Text] [PDF]
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T. F. Shepard, E. A. Platz, P. W. Kantoff, W. G. Nelson, W. B. Isaacs, D. Freije, P. G. Febbo, M. J. Stampfer, and E. Giovannucci No Association between the I105V Polymorphism of the Glutathione S-Transferase P1 Gene (GSTP1) and Prostate Cancer Risk: A Prospective Study Cancer Epidemiol. Biomarkers Prev., November 1, 2000; 9(11): 1267 - 1268. [Full Text]
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P. V. Nerurkar, L. Okinaka, C. Aoki, A. Seifried, A. Lum-Jones, L. R. Wilkens, and L. Le Marchand CYP1A1, GSTM1, and GSTP1 Genetic Polymorphisms and Urinary 1-Hydroxypyrene Excretion in Non-Occupationally Exposed Individuals Cancer Epidemiol. Biomarkers Prev., October 1, 2000; 9(10): 1119 - 1122. [Abstract] [Full Text]
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C. Sweeney, G. Y. McClure, M. Y. Fares, A. Stone, B. F. Coles, P. A. Thompson, S. Korourian, L. F. Hutchins, F. F. Kadlubar, and C. B. Ambrosone Association between Survival after Treatment for Breast Cancer and Glutathione S-Transferase P1 Ile105Val Polymorphism Cancer Res., October 1, 2000; 60(20): 5621 - 5624. [Abstract] [Full Text]
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 R. Raftogianis, C. Creveling, R. Weinshilboum, and J. Weisz Chapter 6: Estrogen Metabolism by Conjugation J Natl Cancer Inst Monographs, July 1, 2000; 2000(27): 113 - 124. [Abstract] [Full Text] [PDF]
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 R Montironi, R Mazzucchelli, D Stramazzotti, R Pomante, D Thompson, and P H Bartels Expression of {pi}-class glutathione S-transferase: two populations of high grade prostatic intraepithelial neoplasia with different relations to carcinoma Mol. Pathol., June 1, 2000; 53(3): 122 - 128. [Abstract] [Full Text]
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F. RODRIGUEZ-FRIAS, C. GONZALEZ, X. COSTA, F. CAMPOS, M. COTRINA, R. JARDI, M. MIRAVITLLES, R. VIDAL;, T. ISHII, S. TERAMOTO, et al. Screening for polymorphisms in exon 5 of the glutathione S-transferase Pl gene Thorax, June 1, 2000; 55(6): 535b - 535. [Full Text]
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A. A. FRYER, A. BIANCO, M. HEPPLE, P. W. JONES, R. C. STRANGE, and M. A. SPITERI Polymorphism at the Glutathione S-transferase GSTP1 Locus . A New Marker for Bronchial Hyperresponsiveness and Asthma Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1437 - 1442. [Abstract] [Full Text]
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C. Sweeney, D. C. Farrow, S. M. Schwartz, D. L. Eaton, H. Checkoway, and T. L. Vaughan Glutathione S-Transferase M1, T1, and P1 Polymorphisms as Risk Factors for Renal Cell Carcinoma: A Case-Control Study Cancer Epidemiol. Biomarkers Prev., April 1, 2000; 9(4): 449 - 454. [Abstract] [Full Text]
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 M. H. WILSON, P. J. GRANT, L. J. HARDIE, and C. P. WILD Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction FASEB J, April 1, 2000; 14(5): 791 - 796. [Abstract] [Full Text]
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E. L. Crawford, S. A. Khuder, S. J. Durham, M. Frampton, M. Utell, W. G. Thilly, D. A. Weaver, W. J. Ferencak, C. A. Jennings, J. R. Hammersley, et al. Normal Bronchial Epithelial Cell Expression of Glutathione Transferase P1, Glutathione Transferase M3, and Glutathione Peroxidase Is Low in Subjects with Bronchogenic Carcinoma Cancer Res., March 1, 2000; 60(6): 1609 - 1618. [Abstract] [Full Text]
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M. Stanulla, M. Schrappe, A. M. Brechlin, M. Zimmermann, and K. Welte Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study Blood, February 15, 2000; 95(4): 1222 - 1228. [Abstract] [Full Text] [PDF]
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 C. L. A. Mann, M. B. Davies, M. D. Boggild, J. Alldersea, A. A. Fryer, P. W. Jones, C. Ko Ko, C. Young, R. C. Strange, and C. P. Hawkins Glutathione S-transferase polymorphisms in MS: Their relationship to disability Neurology, February 8, 2000; 54(3): 552 - 552. [Abstract] [Full Text] [PDF]
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R. M. Whyatt, F. P. Perera, W. Jedrychowski, R. M. Santella, S. Garte, and D. A. Bell Association between Polycyclic Aromatic Hydrocarbon-DNA Adduct Levels in Maternal and Newborn White Blood Cells and Glutathione S-Transferase P1 and CYP1A1 Polymorphisms Cancer Epidemiol. Biomarkers Prev., February 1, 2000; 9(2): 207 - 212. [Abstract] [Full Text]
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S. Rollinson, P. Roddam, E. Kane, E. Roman, R. Cartwright, A. Jack, and G. J. Morgan Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia Carcinogenesis, January 1, 2000; 21(1): 43 - 47. [Abstract] [Full Text] [PDF]
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A. M. Dunning, C. S. Healey, P. D. P. Pharoah, M. D. Teare, B. A. J. Ponder, and D. F. Easton A Systematic Review Of Genetic Polymorphisms and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., October 1, 1999; 8(10): 843 - 854. [Abstract] [Full Text]
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S. Ozawa, B. Schoket, L.P. McDaniel, Y.-M. Tang, C. B. Ambrosone, S. Kostic, I. Vincze, and F. F. Kadlubar Analyses of bronchial bulky DNA adduct levels and CYP2C9, GSTP1 and NQO1 genotypes in a Hungarian study population with pulmonary diseases Carcinogenesis, June 1, 1999; 20(6): 991 - 995. [Abstract] [Full Text] [PDF]
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S. Longuemaux, C. Delomenie, C. Gallou, A. Mejean, M. Vincent-Viry, R. Bouvier, D. Droz, R. Krishnamoorthy, M.-M. Galteau, C. Junien, et al. Candidate Genetic Modifiers of Individual Susceptibility to Renal Cell Carcinoma: A Study of Polymorphic Human Xenobiotic-metabolizing Enzymes Cancer Res., June 1, 1999; 59(12): 2903 - 2908. [Abstract] [Full Text] [PDF]
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X. Hu, C. Herzog, P. Zimniak, and S. V. Singh Differential Protection against Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA Damage in HepG2 Cells Stably Transfected with Allelic Variants of {{pi}} Class Human Glutathione S-Transferase Cancer Res., May 1, 1999; 59(10): 2358 - 2362. [Abstract] [Full Text] [PDF]
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T. R. Rebbeck, A. H. Walker, J. M. Jaffe, D. L. White, A. J. Wein, and S. B. Malkowicz Glutathione S-Transferase-{micro} (GSTM1) and -{theta} (GSTT1) Genotypes in the Etiology of Prostate Cancer1 Cancer Epidemiol. Biomarkers Prev., April 1, 1999; 8(4): 283 - 287. [Abstract] [Full Text] [PDF]
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M. Welfare, A. M. Adeokun, M. F. Bassendine, and A. K. Daly Polymorphisms in GSTP1, GSTM1, and GSTT1 and Susceptibility to Colorectal Cancer1 Cancer Epidemiol. Biomarkers Prev., April 1, 1999; 8(4): 289 - 292. [Abstract] [Full Text] [PDF]
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C. Chen and W. Nirunsuksiri Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture Carcinogenesis, April 1, 1999; 20(4): 699 - 703. [Abstract] [Full Text] [PDF]
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 D. L Mattey, A. B Hassell, M. Plant, P. T Dawes, W. R Ollier, P. W Jones, A. A Fryer, J. E Alldersea, and R. C Strange Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope Ann Rheum Dis, March 1, 1999; 58(3): 164 - 168. [Abstract] [Full Text]
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E. M. M. van Lieshout, H. M. J. Roelofs, S. Dekker, C. J. J. Mulder, T. Wobbes, J. B. M. J. Jansen, and W. H. M. Peters Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett's Esophagus and Esophageal Carcinoma Cancer Res., February 1, 1999; 59(3): 586 - 589. [Abstract] [Full Text] [PDF]
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 W. R. Fields, C. S. Morrow, A. J. Doss, K. Sundberg, B. Jernström, and A. J. Townsend Overexpression of Stably Transfected Human Glutathione S-Transferase P1-1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells Mol. Pharmacol., August 1, 1998; 54(2): 298 - 304. [Abstract] [Full Text]
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C. J. Henderson, A. G. Smith, J. Ure, K. Brown, E. J. Bacon, and C. R. Wolf Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases PNAS, April 28, 1998; 95(9): 5275 - 5280. [Abstract] [Full Text] [PDF]
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J. M. Allan, C. P. Wild, S. Rollinson, E. V. Willett, A. V. Moorman, G. J. Dovey, P. L. Roddam, E. Roman, R. A. Cartwright, and G. J. Morgan Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia PNAS, September 25, 2001; 98(20): 11592 - 11597. [Abstract] [Full Text] [PDF]
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