Carcinogenesis, Vol 19, 711-721, Copyright © 1998 by Oxford University Press
DA Wink, Y Vodovotz, J Laval, F Laval, MW Dewhirst and JB Mitchell
The roles of nitric oxide (NO) in numerous disease states have generated
considerable discussion over the past several years. NO has been labeled as
the causative agent in different pathophysiological mechanisms, yet appears
to protect against various chemical species such as those generated under
oxidative stress. Similarly, NO appears to exert a dichotomy of effects
within the multistage model of cancer. Chronic inflammation can lead to the
production of chemical intermediates, among them NO, which in turn can
mediate damage to DNA. Yet, NO also appears to be critical for the
tumoricidal activity of the immune system. Furthermore, NO can also have a
multitude of effects on other aspects of tumor biology, including
angiogenesis and metastasis. This report will discuss how the chemistry of
NO may impact the initiation and progression stages of cancer.
REVIEWS
The multifaceted roles of nitric oxide in cancer
Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
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