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© 1999 Oxford University Press

Letters To The Editor

Re: Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117–1125.

Ulla Stenius and Johan Högberg

Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171 77 Stockholm, Sweden

The first 10% of the full text of this article appears below.

Dear Sir,

In a recent issue of the Journal, Yang and Duerksen-Hughes present a new in vitro approach for identifying genotoxic carcinogens. In this study they used p53 induction in vitro as an indicator of genotoxic damage. The authors suggest that this endpoint could be used as an effective tool for identifying environmental carcinogens.

In our opinion, p53 induction has clear weaknesses as an endpoint for in vitro genotoxicity testing. It is induced by many types . . . [Full Text of this Article]

P. Duerksen-Hughes


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