Carcinogenesis, Vol. 20, No. 12, 2253-2260,
December 1999
© 1999 Oxford University Press
Molecular Epidemiology and Cancer Prevention |
Studies on the mechanism of cancer protection by wheat bran: effects on the absorption, metabolism and excretion of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences and
1 School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
We examined ways in which dietary supplements of wheat bran may protect against colon cancer. The effects of supplementing the diet of female Wistar rats with 10% wheat bran on the disposition and metabolism of the dietary carcinogen 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) labelled with 14C was determined. Our data show that the wheat bran had a major effect on both the distribution and metabolism of IQ. At a low dose of IQ (1 mg/kg), we unexpectedly found that up to 2 h after gavage there were higher concentrations of radioactivity in the plasma of rats fed wheat bran compared with the controls, but there were lower concentrations of radioactivity after 2 h. At a high dose of IQ (50 mg/kg), there were always lower concentrations of radioactivity in the plasma of rats fed wheat bran compared with the control rats. One of the most marked effects of wheat bran was apparently to significantly retard the metabolism of IQ in the plasma when this was fed at either dose. There were also differences between the rats fed wheat bran and the control in the concentrations and types of IQ metabolites in the urine.
Abbreviations: IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; IQ-N-sulphamate, N-(3-methylimidazo[4,5-f]quinolin-2-yl)sulphamic acid; IQ-5-O-glucuronide, 2-amino-5-(glucosiduronyloxy)-3-methylimidazo[4,5-f]quinoline; IQ-5-O-sulphate, 2-amino-3-methylimidazo[4,5-f]quinolin-5-yl sulphate.
2 To whom correspondence should be addressed Email: l.ferguson{at}aukland.ac.nz
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