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Carcinogenesis, Vol. 21, No. 1, 107-111, January 2000
© 2000 Oxford University Press

Carcinogenesis

Human DNA adducts of 1,3-butadiene, an important environmental carcinogen

Chunyan Zhao2, Pavel Vodicka1, Radim J. Srám11 and Kari Hemminki

Center for Nutrition and Toxicology, Department of Biosciences, Karolinska Institute, NOVUM, 141 57 Huddinge, Sweden and
1 Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnská 1083, 142 20, Prague 4, Czech Republic

Dedicated to the memory of Anthony Dipple.

The N-1-(2,3,4-trihydroxybutyl)adenine (N-1-THB-Ade) adducts induced by 1,3-butadiene (BD) were analysed from lymphocytes of 15 workers occupationally exposed to BD and 11 controls by 32P-post-labelling using HPLC with radioactivity detection. The difference in the adduct levels between the BD-exposed workers (4.5 ± 7.7 adducts/109 nucleotides) and the controls (0.8 ± 1.2 adducts/109 nucleotides) was statistically significant (Wilcoxon rank sum test, P = 0.038). This study shows for the first time BD-induced DNA adducts in humans and suggests that N-1-THB-Ade adducts may be used to biomonitor human exposure to BD.

Abbreviations: BD, 1,3-butadiene; EBD, epoxybutanediol; N-1-THB-Ade, N-1-(2,3,4-trihydroxybutyl)adenine; N6-THB-Ade, N6-(2,3,4-trihydroxybutyl)adenine.

2 To whom correspondence should be addressed Email: chunyan.zhao{at}cnt.ki.se


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