Carcinogenesis, Vol. 21, No. 11, 1965-1969,
November 2000
© 2000 Oxford University Press
Molecular Epidemiology and Cancer Prevention |
Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats
Department of Pharmacology, University of Florence, 6 Viale G.Pieraccini, 50139 Florence,
2 USL 10/H, Antella, Florence,
3 Department of Statistics, University of Florence, 59 Viale Morgagni, 50134 Florence, Italy and
4 Research Unit Biopolymers and Aromas INRA-ISVV, 2 Place Viala, 34060 Montpellier cedex, France
We investigated whether polyphenolic extracts from black tea, green tea or red wine affect azoxymethane (AOM)-induced intestinal carcinogenesis. Male F344 rats were treated 10 times (1 week apart) with AOM (7.4 mg/kg, s.c.) and then allocated into groups receiving black tea, green tea or red wine extracts mixed in the diet at a dose of 50 mg/kg body weight for 16 weeks. In the rats treated with black tea or wine extracts, there were significantly fewer colorectal tumours than in controls (the mean ± SE number of tumours/rat was 2.54 ± 1.6 in controls, 1.54 ± 1.4 in the black tea group, 3.2 ± 1.9 in the green tea group and 1.63 ± 1.6 in the wine extract group). Significantly fewer rats in the black tea and wine extract groups had adenomas than in controls (86%, 59%, 90% and 50% of rats in the control, black tea, green tea and wine extract groups, respectively, had adenomas). The tumours from the black tea group and, to a lesser extent, those from the wine group, had a significantly greater apoptotic index than tumours in controls (mean ± SE apoptotic index: 2.92 ± 0.25, 4.13 ± 0.46, 2.88 ± 0.30 and 3.72 ± 0.46 in controls, black tea, green tea or wine extract groups, respectively). In contrast, the apoptotic index of the normal mucosa did not vary among groups. These data indicate that black tea and wine extracts, but not green tea extracts, can protect against AOM-induced colon carcinogenesis by a mechanism probably involving increased apoptosis in tumours.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Xiao, X. Hao, B. Simi, J. Ju, H. Jiang, B. S. Reddy, and C. S. Yang Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats Carcinogenesis, January 1, 2008; 29(1): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Issa, S. R. Volate, S. J. Muga, D. Nitcheva, T. Smith, and M. J. Wargovich Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model Carcinogenesis, September 1, 2007; 28(9): 1978 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Banerjee, C. Kr. Panda, and S. Das Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer Carcinogenesis, August 1, 2006; 27(8): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Sun, J.-M. Yuan, W.-P. Koh, and M. C. Yu Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies Carcinogenesis, July 1, 2006; 27(7): 1301 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Cheynier Polyphenols in foods are more complex than often thought Am. J. Clinical Nutrition, January 1, 2005; 81(1): 223S - 229S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Crespy and G. Williamson A Review of the Health Effects of Green Tea Catechins in In Vivo Animal Models J. Nutr., December 1, 2004; 134(12): 3431S - 3440S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Y Rios, R. N Bennett, S. A Lazarus, C. Remesy, A. Scalbert, and G. Williamson Cocoa procyanidins are stable during gastric transit in humans Am. J. Clinical Nutrition, November 1, 2002; 76(5): 1106 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Femia, C. Luceri, P. Dolara, A. Giannini, A. Biggeri, M. Salvadori, Y. Clune, K. J. Collins, M. Paglierani, and G. Caderni Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats Carcinogenesis, November 1, 2002; 23(11): 1953 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Leikert;, T. R. Rathel;, P. Wohlfart, V. Cheynier, A. M. Vollmar, and V. M. Dirsch Red Wine Polyphenols Enhance Endothelial Nitric Oxide Synthase Expression and Subsequent Nitric Oxide Release From Endothelial Cells Circulation, September 24, 2002; 106(13): 1614 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Luceri, G. Caderni, A. Sanna, and P. Dolara Red Wine and Black Tea Polyphenols Modulate the Expression of Cycloxygenase-2, Inducible Nitric Oxide Synthase and Glutathione-Related Enzymes in Azoxymethane-Induced F344 Rat Colon Tumors J. Nutr., June 1, 2002; 132(6): 1376 - 1379. [Abstract] [Full Text] [PDF]
|
|