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Carcinogenesis, Vol. 21, No. 2, 307-309, February 2000
© 2000 Oxford University Press

Short Communications

Animal products and K-ras codon 12 and 13 mutations in colon carcinomas

E. Kampman3, D.W. Voskuil, A.A. van Kraats1, H.F. Balder, G.N.P. van Muijen1, R.A. Goldbohm2 and P. van't Veer

Division of Human Nutrition and Epidemiology, Wageningen University, Dreijenlaan 1 (bode 154), 6703 HA Wageningen,
1 Department of Pathology, Nijmegen University Hospital, Nijmegen and
2 Department of Consumer Research and Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands

K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36% harboured mutations, of which 82% were located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios (OR) and 95% confidence intervals (95% CI) for codon 12 versus codon 13 were 9.0 (2.0–42), 4.1 (1.4–12) and 15 (1.4–160), respectively. In case–control comparisons, high intakes of animal protein and calcium were positively associated with colon tumours harbouring codon 12 mutations [for animal protein per 17 g, OR (95% CI) = 1.5 (1.0–2.1); for calcium per 459 mg, 1.2 (0.9–1.6)], while inverse associations were observed for tumours with K-ras mutations in codon 13 [for animal protein 0.4 (0.2–1.0); for calcium 0.6 (0.3–1.2)]. Transition and transversion mutations were not differently associated with these dietary factors. These data suggest a different dietary aetiology of colon tumours harbouring K-ras codon 12 and 13 mutations.

Abbreviations: CI, confidence interval; OR, odds ratio.


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