Carcinogenesis, Vol. 21, No. 3, 397-404,
March 2000
© 2000 Oxford University Press
Carcinogenesis |
Radiation carcinogenesis
Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Research on radiation carcinogenesis during the past 2 decades has focused on cellular and molecular mechanisms for the effects of radiation in mammalian cells. This paper will review several of these areas of research, as they may relate specifically to the induction of cancer by ionizing radiation. Knowledge of the critical DNA damage of biologic importance, and how this damage is repaired, will be discussed in relation to its role in the induction of mutations by radiation. The search for the initiating event in radiation carcinogenesis, as well as other genetic events that may be involved, is discussed in terms of the possible role of the activation of oncogenes or tumor suppressor genes and the loss of cell-cycle checkpoints. Finally, evidence will be described indicating that important genetic consequences of radiation may arise in cells that in themselves receive no direct nuclear irradiation. It has been shown that radiation can, by itself, induce a type of genomic instability in cells, which enhances the rate at which mutations and other genetic changes arise in the descendants of the irradiated cell after many generations of replication. Preliminary evidence has been presented that irradiation targeted to the cytoplasm yields a significant increase in the frequency of mutations. Finally, genetic events including the induction of mutations and changes in gene expression may occur in neighboring cells that receive no direct radiation exposure at all. This `bystander effect' involves gap junction mediated cell–cell communication, and activation of the p53 damage response pathway. The possible role of these phenomena in radiation carcinogenesis is discussed.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Marusyk, M. Casas-Selves, C. J. Henry, V. Zaberezhnyy, J. Klawitter, U. Christians, and J. DeGregori Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors Cancer Res., September 15, 2009; 69(18): 7262 - 7269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E M M Cerqueira, J R C Meireles, M A Lopes, V C Junqueira, I S Gomes-Filho, S Trindade, and G M Machado-Santelli Genotoxic effects of X-rays on keratinized mucosa cells during panoramic dental radiography Dentomaxillofac. Radiol., October 1, 2008; 37(7): 398 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-Y. Chiang, C.-W. Wu, P.-J. Hsiao, W.-R. Kuo, K.-W. Lee, J.-C. Lin, Y.-C. Liao, and S.-H. H. Juo Association between Polymorphisms in DNA Base Excision Repair Genes XRCC1, APE1, and ADPRT and Differentiated Thyroid Carcinoma Clin. Cancer Res., September 15, 2008; 14(18): 5919 - 5924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Loeb and C. C. Harris Advances in Chemical Carcinogenesis: A Historical Review and Prospective Cancer Res., September 1, 2008; 68(17): 6863 - 6872. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mancuso, E. Pasquali, S. Leonardi, M. Tanori, S. Rebessi, V. Di Majo, S. Pazzaglia, M. P. Toni, M. Pimpinella, V. Covelli, et al. From the Cover: Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum PNAS, August 26, 2008; 105(34): 12445 - 12450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lu, L.-E Wang, P. Xiong, E. M. Sturgis, M. R. Spitz, and Q. Wei 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant Carcinogenesis, May 1, 2007; 28(5): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liang, M. S. Mendonca, L. Deng, S. C. Nguyen, C. Shao, and J. A. Tischfield Reduced Apoptosis and Increased Deletion Mutations at Aprt Locus In vivo in Mice Exposed to Repeated Ionizing Radiation Cancer Res., March 1, 2007; 67(5): 1910 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Huang, P. M. Kim, J. A. Nickoloff, and W. F. Morgan Targeted and Nontargeted Effects of Low-Dose Ionizing Radiation on Delayed Genomic Instability in Human Cells Cancer Res., February 1, 2007; 67(3): 1099 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Vilenchik and A. G. Knudson Radiation dose-rate effects, endogenous DNA damage, and signaling resonance PNAS, November 21, 2006; 103(47): 17874 - 17879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Kim, G. M. Fiskum, and W. F. Morgan A Role for Mitochondrial Dysfunction in Perpetuating Radiation-Induced Genomic Instability Cancer Res., November 1, 2006; 66(21): 10377 - 10383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J.Kim, K. Chandrasekaran, and W. F.Morgan Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review Mutagenesis, November 1, 2006; 21(6): 361 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gonin-Laurent, A. Gibaud, M. Huygue, S. H. Lefevre, M. Le Bras, L. Chauveinc, X. Sastre-Garau, F. Doz, L. Lumbroso, S. Chevillard, et al. Specific TP53 mutation pattern in radiation-induced sarcomas Carcinogenesis, June 1, 2006; 27(6): 1266 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L E Feinendegen and R D Neumann The issue of risk in complex adaptive systems: the case of low-dose radiation induced cancer Human and Experimental Toxicology, January 1, 2006; 25(1): 11 - 17. [Abstract] [PDF]
|
|
|
|
 |
|
 A. S. Rodrigues, N. G. Oliveira, O. M. Gil, A. Leonard, and J. Rueff Use of cytogenetic indicators in radiobiology Radiat Prot Dosimetry, December 20, 2005; 115(1-4): 455 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Feinendegen and R. D. Neumann Physics must join with biology in better assessing risk from low-dose irradiation Radiat Prot Dosimetry, December 1, 2005; 117(4): 346 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukushima, A. Kinoshita, R. Puatanachokchai, M. Kushida, H. Wanibuchi, and K. Morimura Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens Carcinogenesis, November 1, 2005; 26(11): 1835 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Baverstock and O. V Belyakov Classical radiation biology, the bystander effect and paradigms: a reply Human and Experimental Toxicology, October 1, 2005; 24(10): 537 - 542. [Abstract] [PDF]
|
|
|
|
|
|
M. Lobrich, N. Rief, M. Kuhne, M. Heckmann, J. Fleckenstein, C. Rube, and M. Uder In vivo formation and repair of DNA double-strand breaks after computed tomography examinations PNAS, June 21, 2005; 102(25): 8984 - 8989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shao, M. Folkard, B. D. Michael, and K. M. Prise Targeted cytoplasmic irradiation induces bystander responses PNAS, September 14, 2004; 101(37): 13495 - 13500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. van Haaften, N. L. Vastenhouw, E. A. A. Nollen, R. H. A. Plasterk, and M. Tijsterman Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality PNAS, August 31, 2004; 101(35): 12992 - 12996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sakata, J. Inoue, H. Ohi, H. Kosugi-Okano, Y. Mishima, K. Hatakeyama, O. Niwa, and R. Kominami Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in {gamma}-ray-induced thymic lymphomas and in normal thymus of the mouse Carcinogenesis, June 1, 2004; 25(6): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mercier, N. Berthault, J. Mary, J. Peyre, A. Antoniadis, J.-P. Comet, A. Cornuejols, C. Froidevaux, and M. Dutreix Biological detection of low radiation doses by combining results of two microarray analysis methods Nucleic Acids Res., January 13, 2004; 32(1): e12 - e12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kodama, Y. Yoshikai, Y. Tamura, S. Wakana, R. Takagi, O. Niwa, and R. Kominami The D5Mit7 locus on mouse chromosome 5 provides resistance to {gamma}-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas Carcinogenesis, January 1, 2004; 25(1): 143 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shao, V. Stewart, M. Folkard, B. D. Michael, and K. M. Prise Nitric Oxide-Mediated Signaling in the Bystander Response of Individually Targeted Glioma Cells Cancer Res., December 1, 2003; 63(23): 8437 - 8442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Brenner, R. Doll, D. T. Goodhead, E. J. Hall, C. E. Land, J. B. Little, J. H. Lubin, D. L. Preston, R. J. Preston, J. S. Puskin, et al. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know PNAS, November 25, 2003; 100(24): 13761 - 13766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Cabelof, Z. Guo, J. J. Raffoul, R. W. Sobol, S. H. Wilson, A. Richardson, and A. R. Heydari Base Excision Repair Deficiency Caused by Polymerase {beta} Haploinsufficiency: Accelerated DNA Damage and Increased Mutational Response to Carcinogens Cancer Res., September 15, 2003; 63(18): 5799 - 5807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. SHAO, Y. FURUSAWA, Y. KOBAYASHI, T. FUNAYAMA, and S. WADA Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study FASEB J, August 1, 2003; 17(11): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Garaj-Vrhovac and N. Kopjar The alkaline Comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation Mutagenesis, May 1, 2003; 18(3): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Minter, E. S. Dickinson, S. P. Naber, and D. J. Jerry Epithelial cell cycling predicts p53 responsiveness to {gamma}-irradiation during post-natal mammary gland development Development, March 8, 2003; 129(12): 2997 - 3008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuki, S. Yokoyama, S. Waseda, S. Kodama, and M. Watanabe Delayed Reactivation of p53 in the Progeny of Cells Surviving Ionizing Radiation Cancer Res., March 1, 2003; 63(5): 936 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nagar, L. E. Smith, and W. F. Morgan Characterization of a Novel Epigenetic Effect of Ionizing Radiation: The Death-Inducing Effect Cancer Res., January 15, 2003; 63(2): 324 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Barber, M. A. Plumb, E. Boulton, I. Roux, and Y. E. Dubrova Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice PNAS, May 14, 2002; 99(10): 6877 - 6882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-H. Yih, K. Peck, and T.-C. Lee Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment Carcinogenesis, May 1, 2002; 23(5): 867 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. N. Ponomareva, J. A. Rose, M. Lasarev, J. Rasey, and M. S. Turker Tissue-specific Deletion and Discontinuous Loss of Heterozygosity Are Signatures for the Mutagenic Effects of Ionizing Radiation in Solid Tissues Cancer Res., March 1, 2002; 62(5): 1518 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bortoletto, M. Mognato, P. Ferraro, S. Canova, R. Cherubini, L. Celotti, and A. Russo Chromosome instability induced in the cell progeny of human T lymphocytes irradiated in G0 with {gamma}-rays Mutagenesis, November 1, 2001; 16(6): 529 - 537. [Abstract] [Full Text] [PDF]
|
|