Carcinogenesis, Vol. 21, No. 4, 623-627,
April 2000
© 2000 Oxford University Press
Molecular Epidemiology and Cancer Prevention |
Estrogen receptor 
gene polymorphisms and endometrial cancer risk
Department of Medical Epidemiology, Karolinska Institutet, PO Box 281, 171 77 Stockholm, Sweden,
1 Department of Internal Medicine, Akademiska Sjukhuset, Uppsala, Sweden and
2 Department of Medicine and Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
Since the estrogen receptor 
(ER) is an important mediator of hormonal responses such as proliferation in estrogen-sensitive tissues, we hypothesized that polymorphisms in the ER gene could be functional and associated with endometrial cancer risk. We performed a population-based case–control study in Sweden, focusing on restriction fragment length polymorphisms for XbaI and PvuII and an upstream TA repeat polymorphism. In the main analysis, 154 cases and 205 controls who never used hormone replacement therapy took part and we calculated age-adjusted and multivariate odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression. The XbaI X allele appeared to confer a reduced risk for endometrial cancer. The multivariate OR for the XX genotype was 0.52 (95% CI 0.21–1.29) compared to the xx genotype and there were suggestions of decreasing risk with increasing number of X alleles (P for trend = 0.07). The PvuII PP genotype was also associated with a non-significantly decreased risk for endometrial cancer (multivariate OR 0.70, 95% CI 0.34–1.44) compared with the pp genotype (P for trend = 0.43). The multivariate OR for two short TA (<19 repeats) alleles versus two long alleles was 1.54 (95% CI 0.73–3.27) and there were suggestions of increasing risk with increasing number of short alleles (P for trend = 0.26). We observed the same pattern of results in an expanded group of subjects, which included women who had used hormone replacement (in total 288 cases and 392 controls). Our data suggest that variants of the ER gene may be associated with an altered risk of endometrial cancer.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. H. McIntyre, P. W. Kantoff, M. J. Stampfer, L. A. Mucci, D. Parslow, H. Li, J. M. Gaziano, M. Abe, and J. Ma Prostate Cancer Risk and ESR1 TA, ESR2 CA Repeat Polymorphisms Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2233 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Alevizaki, K Saltiki, A Cimponeriu, I Kanakakis, N Xita, C C Alevizaki, I Georgiou, and H-L Sarika Severity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor {alpha} polymorphic variants Eur. J. Endocrinol., April 1, 2007; 156(4): 489 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Kjaergaard, C. Ellervik, A. Tybjaerg-Hansen, C. K. Axelsson, M.-L. M. Gronholdt, P. Grande, G. B. Jensen, and B. G. Nordestgaard Estrogen Receptor {alpha} Polymorphism and Risk of Cardiovascular Disease, Cancer, and Hip Fracture: Cross-Sectional, Cohort, and Case-Control Studies and a Meta-Analysis Circulation, February 20, 2007; 115(7): 861 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhao, L. Xu, M. Otsuki, G. Toresson, K. Koehler, Q. Pan-Hammarstrom, L. Hammarstrom, S. Nilsson, J.-A. Gustafsson, and K. Dahlman-Wright Identification of a functional variant of estrogen receptor beta in an African population Carcinogenesis, November 1, 2004; 25(11): 2067 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y J Lee, K S Shin, S W Kang, C K Lee, B Yoo, H S Cha, E M Koh, S J Yoon, and J Lee Association of the oestrogen receptor {alpha} gene polymorphisms with disease onset in systemic lupus erythematosus Ann Rheum Dis, October 1, 2004; 63(10): 1244 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. E. Schuit, J. B. J. van Meurs, A. P. Bergink, M. van der Klift, Y. Fang, G. Leusink, A. Hofman, J. P. T. M. van Leeuwen, A. G. Uitterlinden, and H. A. P. Pols Height in Pre- and Postmenopausal Women Is Influenced by Estrogen Receptor {alpha} Gene Polymorphisms J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 303 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Hopkins and E. A. Brinton Estrogen Receptor 1 Variants and Coronary Artery Disease: Shedding Light Into a Murky Pool JAMA, November 5, 2003; 290(17): 2317 - 2319. [Full Text] [PDF]
|
|
|
|
|
|
Q. Cai, X.-O. Shu, F. Jin, Q. Dai, W. Wen, J.-R. Cheng, Y.-T. Gao, and W. Zheng Genetic Polymorphisms in the Estrogen Receptor {alpha} Gene and Risk of Breast Cancer: Results from the Shanghai Breast Cancer Study Cancer Epidemiol. Biomarkers Prev., September 1, 2003; 12(9): 853 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B.J. van Meurs, S. C.E. Schuit, A. E.A.M. Weel, M. van der Klift, A. P. Bergink, P. P. Arp, E. M. Colin, Y. Fang, A. Hofman, C. M. van Duijn, et al. Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk Hum. Mol. Genet., July 15, 2003; 12(14): 1745 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Stavrou, C. Zois, J.P.A. Ioannidis, and A. Tsatsoulis Association of polymorphisms of the oestrogen receptor{alpha} gene with the age of menarche Hum. Reprod., April 1, 2002; 17(4): 1101 - 1105. [Abstract] [Full Text] [PDF]
|
|