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Carcinogenesis, Vol. 21, No. 5, 1063-1066, May 2000
© 2000 Oxford University Press

Short Communications

Expression of PGF2{alpha} receptor mRNA in normal, hyperplastic and neoplastic skin

Karsten Müller, Peter Krieg, Friedrich Marks and Gerhard Fürstenberger1

Research Program Tumor Cell Regulation, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

Reverse transcription polymerase chain reaction (RT–PCR) and Northern blot analysis was used to determine the level of expression of prostaglandin F2{alpha} (FP) receptor mRNA in various mouse tissues, including normal, hyperplastic and neoplastic mouse epidermis. Steady-state concentrations of FP receptor mRNA were low in normal and hyperplastic epidermis. The response of the epidermis to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was biphasic in that FP receptor mRNA was increased immediately after treatment, followed by a long-lasting down-regulation at later time points. FP receptor mRNA was down-regulated in the majority of papillomas obtained by the mouse skin carcinogenesis initiation–promotion protocol. In carcinomas, FP receptor mRNA expression was similar to that in normal epidermis. The steady-state concentration of FP mRNA was inversely correlated with PGF2{alpha} levels in normal and hyperplastic epidermis and in papillomas, indicating that FP mRNA expression is regulated by this eicosanoid.


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