Carcinogenesis, Vol. 21, No. 5, 865-869,
May 2000
© 2000 Oxford University Press
Commentaries |
The INK4a/ARF locus in murine tumorigenesis
Department of Immunology and Oncology, Centro Nacional de Biotecnología, Campus de Cantoblanco, Madrid E-28049, Spain Email: mserrano{at}cnb.uam.es
Abstract
The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16INK4a and p19ARF, has provided a great insight on the functioning of the tumor suppressors Rb and p53, respectively. Present evidence indicates that the INK4a/ARF locus is transcriptionally activated by oncogenic stresses, resulting in cell-cycle arrest or apoptosis. Here, I review the evidence accumulated on the involvement of the INK4a/ARF locus in murine tumorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. M. Moore, K. M. Holmes, S. M. Smith, Y. Wu, E. Tchougounova, L. Uhrbom, R. Sawaya, J. M. Bruner, G. N. Fuller, and W. Zhang IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas PNAS, September 29, 2009; 106(39): 16675 - 16679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Morrison, H. Satoh, J. Foley, J. L. Horton, J. K. Dunnick, G. E. Kissling, and D. E. Malarkey N-ethyl-N-nitrosourea (ENU)-Induced Meningiomatosis and Meningioma in p16INK4a/p19ARF Tumor Suppressor Gene-Deficient Mice Toxicol Pathol, October 1, 2007; 35(6): 838 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Knowles Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? Carcinogenesis, March 1, 2006; 27(3): 361 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Chapman, P. Harnden, P. Chambers, C. Johnston, and M. A. Knowles Comprehensive Analysis of CDKN2A Status in Microdissected Urothelial Cell Carcinoma Reveals Potential Haploinsufficiency, a High Frequency of Homozygous Co-deletion and Associations with Clinical Phenotype Clin. Cancer Res., August 15, 2005; 11(16): 5740 - 5747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Meuwissen and A. Berns Mouse models for human lung cancer Genes & Dev., March 15, 2005; 19(6): 643 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Aveyard and M. A. Knowles Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification J. Mol. Diagn., November 1, 2004; 6(4): 356 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sandoval, J. Xue, M. Pilkinton, D. Salvi, H. Kiyokawa, and O. R. Colamonici Different Requirements for the Cytostatic and Apoptotic Effects of Type I Interferons: INDUCTION OF APOPTOSIS REQUIRES ARF BUT NOT p53 IN OSTEOSARCOMA CELL LINES J. Biol. Chem., July 30, 2004; 279(31): 32275 - 32280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D'Amico, K. Wu, M. Fu, M. Rao, C. Albanese, R. G. Russell, H. Lian, D. Bregman, M. A. White, and R. G. Pestell The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame (INK4a/ARF) Locus Encoded Proteins p16INK4a and p19ARF Repress Cyclin D1 Transcription through Distinct cis Elements Cancer Res., June 15, 2004; 64(12): 4122 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Macdiarmid, D. Stevenson, D. H. Campbell, and J. B. Wilson The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo Carcinogenesis, July 1, 2003; 24(7): 1209 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D'Amico, K. Wu, D. Di Vizio, A. T. Reutens, M. Stahl, M. Fu, C. Albanese, R. G. Russell, W. J. Muller, M. White, et al. The Role of Ink4a/Arf in ErbB2 Mammary Gland Tumorigenesis Cancer Res., June 15, 2003; 63(12): 3395 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Nambiar, C. Giardina, K. Guda, W. Aizu, R. Raja, and D. W. Rosenberg Role of the Alternating Reading Frame (P19)-p53 Pathway in an in Vivo Murine Colon Tumor Model Cancer Res., July 1, 2002; 62(13): 3667 - 3674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. Baxter, K. Blyth, E. R. Cameron, and J. C. Neil Selection for Loss of p53 Function in T-Cell Lymphomagenesis Is Alleviated by Moloney Murine Leukemia Virus Infection in myc Transgenic Mice J. Virol., October 15, 2001; 75(20): 9790 - 9798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Nicholson, N. T. Okby, M. A. Khan, J. A. Welsh, M. G. McMenamin, W. D. Travis, J. R. Jett, H. D. Tazelaar, V. Trastek, P. C. Pairolero, et al. Alterations of p14ARF, p53, and p73 Genes Involved in the E2F-1-mediated Apoptotic Pathways in Non-Small Cell Lung Carcinoma Cancer Res., July 1, 2001; 61(14): 5636 - 5643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dai and S. B. Krantz Increased expression of the INK4a/ARF locus in polycythemia vera Blood, June 1, 2001; 97(11): 3424 - 3432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lu, H. Lian, P. Sharma, N. Schreiber-Agus, R. G. Russell, L. Chin, G. T. J. van der Horst, and D. B. Bregman Disruption of the Cockayne Syndrome B Gene Impairs Spontaneous Tumorigenesis in Cancer-Predisposed Ink4a/ARF Knockout Mice Mol. Cell. Biol., March 1, 2001; 21(5): 1810 - 1818. [Abstract] [Full Text]
|
|
|
|
 |
|
 D.O. FERGUSON, J.M. SEKIGUCHI, K.M. FRANK, Y. GAO, N.E. SHARPLESS, Y. GU, J. MANIS, R.A. DEPINHO, and F.W. ALT The Interplay between Nonhomologous End-joining and Cell Cycle Checkpoint Factors in Development, Genomic Stability, and Tumorigenesis Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 395 - 404. [Abstract] [PDF]
|
|