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Carcinogenesis, Vol. 22, No. 2, 251-256, February 2001
© 2001 Oxford University Press

CANCER BIOLOGY

HMGI-C gene expression is not required for in vivo thyroid cell transformation

Stefania Scala, Giuseppe Portella, Donatella Vitagliano, Catherine Ledent1, Gennaro Chiappetta2, Vincenzo Giancotti3, Jacques Dumont1 and Alfredo Fusco4,5

Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli `Federico II', via Pansini, 5, 80131 Naples, Italy,
1 Université Libre de Bruxelles, Facultè de Medecine, Institute de Recherches Interdisciplinaires Campus Erasme, Bruxelles, Belgium,
2 Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, via M. Semmola, 80131 Naples, Italy,
3 Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita' degli Studi di Trieste, 34127 Trieste, Italy and
4 Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia di Catanzaro, Università di Catanzaro, via Tommaso Campanella, 88100 Catanzaro, Italy

We have previously demonstrated that HMGI proteins are required for the transformation of rat thyroid cells by v-mos and v-ras-Ki oncogenes. To determine whether HMGI proteins are also required for in vivo thyroid carcinogenesis, mice carrying a disrupted HMGI-C gene (pygmy mice) were either treated with radioactive iodine or crossed with transgenic mice carrying the E7 papilloma virus oncogene under the transcriptional control of thyroglobulin gene promoter. The pygmy mice developed thyroid carcinomas with the same frequency as occurred in wild-type mice without significant macroscopic and microscopic differences. Therefore, these results indicate that HMGI-C gene expression is not required in in vivo thyroid cell malignant transformation.


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