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Carcinogenesis, Vol. 22, No. 5, 821-825, May 2001
© 2001 Oxford University Press

SHORT COMMUNICATION

Curcumin modifies Apcmin apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apcmin mice

Gavin Patrick Collett, Craig Nigel Robson1,, John Cummings Mathers2, and Frederick Charles Campbell3,

Department of Surgery, The Cancer Centre, Queen's University Belfast, Grosvenor Road, Belfast, BT12 6BJ and
1 Department of Surgery and
2 Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK

Curcumin, the active ingredient of the rhizome of Curcuma longa, promotes apoptosis and may have chemopreventive properties. This study investigates the effects of curcumin on apoptosis and tumorigenesis in male Apcmin mice treated with the human dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Intestinal epithelial apoptotic index in response to PhIP treatment was approximately twice as great in the wild-type C57BL/6 APC+/+ strain than in Apcmin mice (3.7% Apc+/+ versus 1.9% Apcmin ; P < 0.001). PhIP promoted tumour formation in Apcmin proximal small intestine (4.6 tumours per mouse, PhIP treated versus 2.1 tumours per mouse, control untreated; P < 0.05). Curcumin enhanced PhIP-induced apoptosis (4.0% curcumin + PhIP versus 2.1% PhIP alone; P < 0.01) and inhibited PhIP-induced tumorigenesis in the proximal small intestine of Apcmin mice (2.2 tumours per mouse, curcumin + PhIP versus 4.6 tumours per mouse PhIP alone; P < 0.05). This study shows that the Apcmin genotype is associated with resistance to PhIP-induced apoptosis in intestinal epithelium. Curcumin attenuates Apcmin resistance to PhIP-induced apoptosis and inhibits PhIP-induced tumorigenesis in proximal Apcmin mouse small intestine.


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