Carcinogenesis, Vol. 22, No. 8, 1111-1117,
August 2001
© 2001 Oxford University Press
COMMENTARY |
A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol
Laboratoire de Pharmacognosie et Bromatologie (CP205-4) and
2 Laboratoire de Physiologie et Pharmacologie Fondamentales (CP205-7), Institut de Pharmacie, Université Libre de Bruxelles, Campus Plaine, Boulevard du Triomphe, 1050 Brussels, Belgium and
3 Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes, France
Resveratrol, a phytoalexin found in grapes and wines, has been reported to exhibit a wide range of pharmacological properties and is believed to play a role in the prevention of human cardiovascular disease (the so-called `French paradox'). This molecule may also play a major role in both cancer prevention and therapy. In this review article we summarize the recent advances that have provided new insights into the molecular mechanisms underlying the promising properties of resveratrol. These include cyclooxygenase, nitric oxide synthase and cytochrome P450 inhibition, as well as cell cycle effects, apoptosis modulation and hormonal activity.
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