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Carcinogenesis, Vol. 23, No. 10, 1767-1768, October 2002
© 2002 Oxford University Press

LETTER TO THE EDITOR

Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol-Certain health supplements may cause both carcinogenic and anticarcinogenic effects

Frank Johnson and James Huff

National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA

The first 10% of the full text of this article appears below.

Stoner et al. (1) described a multi-organ rat model, following earlier work (2,3), and analyzed the effects of indole-3-carbinol (I-3-C) on 7,12-dimethylbenz[a]anthracene (DMBA)-, azoxymethane (AOM)- and aflatoxin B1 (AFB1)-induced tumor development in colon, mammary gland and liver. They reported that although I-3-C is sold without prescription as an antiestrogenic chemopreventive agent in health food stores, a combination of anticarcinogenic and carcinogenic effects were induced in their model system. Thus, I-3-C appears to retard the rate of mammary tumor development by extending latency, but does not seem to affect mammary tumor incidence, tumor multiplicity or survival. Furthermore, . . . [Full Text of this Article]


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