Carcinogenesis, Vol. 23, No. 2, 289-294,
February 2002
© 2002 Oxford University Press
MOLECULAR EPIDEMIOLOGY |
Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents
Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Abstract
Male strain A mice were fed a diet containing chemopreventive agents. After 1 and 3 weeks on the diets, lung nuclear fractions were examined for expression of cyclin D1/2 with western blot analysis. In animals fed a diet containing a mixture of myoinositol and dexamethasone, a treatment found previously to be effective in preventing the development of tobacco smoke-induced lung tumors in A/J mice, cyclin D1/2 expression was reduced to 30–40% of control levels. A similar decrease in cyclin D1/2 expression was found when animals were fed either myoinositol or dexamethasone alone. Paradoxically, tobacco smoke by itself had a similar effect on cyclin D1/2 expression. On the other hand, several agents that had been previously found not to be effective against tobacco smoke carcinogenesis [phenethyl isothiocyanate, 1,4-phenylenebis(methylene)selenoisocyanate, N-acetylcysteine, acetylsalicylic acid, D-limonene and beta carotene] did not decrease cyclin D1/2 expression after 1 or 3 weeks of feeding. It was concluded that expression of cyclin D1/2 might be a potentially useful marker in the identification of chemopreventive agents for tobacco smoke and could be of some help in the evaluation of their effects.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Liby, C. C. Black, D. B. Royce, C. R. Williams, R. Risingsong, M. M. Yore, X. Liu, T. Honda, G. W. Gribble, W. W. Lamph, et al. The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis Mol. Cancer Ther., May 1, 2008; 7(5): 1251 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ma, Q. Feng, D. Sekula, J. A. Diehl, S. J. Freemantle, and E. Dmitrovsky Retinoid Targeting of Different D-Type Cyclins through Distinct Chemopreventive Mechanisms Cancer Res., July 15, 2005; 65(14): 6476 - 6483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Pitha-Rowe, W. J. Petty, Q. Feng, P. H. Koza-Taylor, D. A. DiMattia, L. Pinder, K. H. Dragnev, N. Memoli, V. Memoli, T. Turi, et al. Microarray Analyses Uncover UBE1L as a Candidate Target Gene for Lung Cancer Chemoprevention Cancer Res., November 1, 2004; 64(21): 8109 - 8115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Palozza, S. Serini, F. Di Nicuolo, A. Boninsegna, A. Torsello, N. Maggiano, F. O. Ranelletti, F. I. Wolf, G. Calviello, and A. Cittadini {beta}-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate Carcinogenesis, August 1, 2004; 25(8): 1315 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Dragnev, I. Pitha-Rowe, Y. Ma, W. J. Petty, D. Sekula, B. Murphy, M. Rendi, N. Suh, N. B. Desai, M. B. Sporn, et al. Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy Clin. Cancer Res., April 1, 2004; 10(7): 2570 - 2577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Neuhouser, R. E. Patterson, M. D. Thornquist, G. S. Omenn, I. B. King, and G. E. Goodman Fruits and Vegetables Are Associated with Lower Lung Cancer Risk Only in the Placebo Arm of the {beta}-Carotene and Retinol Efficacy Trial (CARET) Cancer Epidemiol. Biomarkers Prev., April 1, 2003; 12(4): 350 - 358. [Abstract] [Full Text] [PDF]
|
|