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Carcinogenesis, Vol. 23, No. 4, 595-598, April 2002
© 2002 Oxford University Press

MOLECULAR EPIDEMIOLOGY

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

Zeki Topcu1,6,7, Itsuo Chiba2, Masaki Fujieda1,6, Toshiyuki Shibata3, Noritaka Ariyoshi1, Hiroshi Yamazaki1, Figen Sevgican1,8, Malsantha Muthumala4, Hiroshi Kobayashi5 and Tetsuya Kamataki1,9

1 Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences,
2 Department of Oral Patho-biological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-0812, Japan,
3 Department of Oral and Maxillofacial Surgery, Gifu University School of Medicine, Tsukasa-cho, Gifu, Japan,
4 Oral and Maxillofacial Unit, General Hospital Kalutara, Sri Lanka,
5 Sapporo Cancer Seminar Foundation, Sapporo, Japan and
6 Organization for Pharmaceutical Safety and Research (OPSR), Tokyo, Japan

Abstract

We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was significantly lower in the case subjects than the controls. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.14 (95% CI; 0.03–0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers.


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