Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Takahashi, Y.
Right arrow Articles by Ishikawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takahashi, Y.
Right arrow Articles by Ishikawa, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol. 23, No. 4, 627-633, April 2002
© 2002 Oxford University Press

CARCINOGENESIS

Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice

Yoshihisa Takahashi1, Yoko Nakatsuru1, Shaomin Zhang1, Yasuhito Shimizu1, Haruki Kume1, Kiyoji Tanaka2, Fumio Ide1 and Takatoshi Ishikawa3,4

1 Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033,
2 Institute for Molecular and Cellular Biology, Osaka University, 1–3 Yamadaoka, Suita, Osaka 565-0871 and
3 National Institution for Academic Degrees, Faculty of University Evaluation and Research, 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo 101-0003, Japan

Xeroderma pigmentosum (XP) is an autosomal recessive hereditary disease featuring defective nucleotide excision repair (NER). XP patients are highly sensitive to sunlight and develop skin cancer at an early age. While the fact that XP patients have a large increase in mortality from skin cancers has been extensively documented, the relation between XP and internal tumors has received little attention. We therefore analyzed development of spontaneous and aflatoxin B1 (AFB1)-induced liver tumors in XPA-deficient congenic mice, originally created by repeated back-crosses with inbred C3H/HeN mice. Spontaneous liver tumors were assessed at the age of 16 months in two separate experiments using F5 and F10 lines. The incidence of and average number of spontaneous tumors per mouse were significantly higher in XPA-/- than in XPA+/+ and +/- mice. Similarly, F10 XPA-/- mice receiving i.p. injection of 0.6 or 1.5 mg/kg b.w. AFB1 at 7 days of age demonstrated more liver tumors than their heterozygous or homozygous positive counterparts when examined at month 11. These results demonstrate that XPA-deficient mice have increased susceptibility to both spontaneous liver tumor development and AFB1-induced hepatocarcinogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
L. L. Bedard, M. Alessi, S. Davey, and T. E. Massey
Susceptibility to Aflatoxin B1-Induced Carcinogenesis Correlates with Tissue-Specific Differences in DNA Repair Activity in Mouse and in Rat
Cancer Res., February 15, 2005; 65(4): 1265 - 1270.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. M. Hoogervorst, C. Th. M. van Oostrom, R. B. Beems, J. van Benthem, S. Gielis, J. P. Vermeulen, P. W. Wester, J. G. Vos, A. de Vries, and H. van Steeg
p53 Heterozygosity Results in an Increased 2-Acetylaminofluorene-Induced Urinary Bladder but not Liver Tumor Response in DNA Repair-Deficient Xpa Mice
Cancer Res., August 1, 2004; 64(15): 5118 - 5126.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. O. Alekseyev, M. L. Hamm, and J. M. Essigmann
Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo
Carcinogenesis, June 1, 2004; 25(6): 1045 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Ide, M. Kitada, H. Sakashita, K. Kusama, K. Tanaka, and T. Ishikawa
p53 Haploinsufficiency Profoundly Accelerates the Onset of Tongue Tumors in Mice Lacking the Xeroderma Pigmentosum Group A Gene
Am. J. Pathol., November 1, 2003; 163(5): 1729 - 1733.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.