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Carcinogenesis, Vol. 23, No. 8, 1263-1265, August 2002
© 2002 Oxford University Press

COMMENTARY

The effect of ß-carotene on lung and skin carcinogenesis

George Wolf

Department of Nutritional Sciences and Toxicology, University of California, Berkeley CA 94720-3104, USA

The induction of pre-cancerous squamous metaplasia in lungs of ferrets by high doses of dietary ß-carotene (BC) and cigarette smoke is compared with and contrasted to the different effects of high doses of dietary BC on skin papilloma and carcinoma induction by the two-stage carcinogenesis protocol. Whereas high dietary BC can inhibit the conversion of skin papillomas to carcinomas, such treatment would not be expected to inhibit smoke-induced lung tumors.


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 J. Nutr.Home page
C. Liu, R. M. Russell, and X.-D. Wang
Low Dose {beta}-Carotene Supplementation of Ferrets Attenuates Smoke-Induced Lung Phosphorylation of JNK, p38 MAPK, and p53 Proteins
J. Nutr., October 1, 2004; 134(10): 2705 - 2710.
[Abstract] [Full Text] [PDF]


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