Carcinogenesis, Vol. 23, No. 8, 1343-1350,
August 2002
© 2002 Oxford University Press
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION |
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
1 INSERM U521, EMI 00–06, Evry, France,
2 International Agency for Cancer Research, Lyon, France,
3 Karolinska Institutet and National Institute for Working Life, Stockholm, Sweden,
4 Geneva Cancer Registry, Switzerland,
5 Centre of Oncology, Gliwice, Poland,
6 Georg-August-University, Göttingen, Germany,
7 Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA,
8 University of Newcastle, UK,
9 University of Ljubljana, Slovenia,
10 Columbia College of Physicians and Surgeons, New York, USA,
11 Ospedale Maggiore IRCCS, Milan, Italy,
12 National Institute of Occupational Health, Oslo, Norway,
13 Finnish Institute of Occupational Health, Helsinki, Finland,
14 P.J. Safarik University, Kosice, Slovakia,
15 Kyoto University School of Public Health, Kyoto, Japan,
16 Institut de Pathologie, Liège, Belgium,
17 University of Hawaii, Honolulu, Hawaii USA,
18 National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA,
19 Oregon Health Sciences University, Oregon, USA,
20 Nagasaki University Graduate School of Medicine, Nagasaki, Japan,
21 University of Pittsburgh, Pennsylvania, USA,
22 Lund University, Lund, Sweden,
23 Georgetown University Medical Center, Washington, DC, USA,
24 Keele University, Staffordshire, UK,
25 INSERM U170, Villejuif, France and
26 Hospital Clinic Provincial, Barcelona, Spain
Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including >18 000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.07–1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publication bias in our results. A pooled analysis of the original data of about 9500 subjects involved in 21 case-control studies from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of GSTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95% CI 0.98–1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. M. Rudin, E. Avila-Tang, C. C. Harris, J. G. Herman, F. R. Hirsch, W. Pao, A. G. Schwartz, K. H. Vahakangas, and J. M. Samet Lung Cancer in Never Smokers: Molecular Profiles and Therapeutic Implications Clin. Cancer Res., September 15, 2009; 15(18): 5646 - 5661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Sanderson, S. C. O'Neill, D. B. White, G. Bepler, L. Bastian, I. M. Lipkus, and C. M. McBride Responses to Online GSTM1 Genetic Test Results among Smokers Related to Patients with Lung Cancer: A Pilot Study Cancer Epidemiol. Biomarkers Prev., July 1, 2009; 18(7): 1953 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Cote, W. Yoo, A. S. Wenzlaff, G. M. Prysak, S. K. Santer, G. B. Claeys, A. L. Van Dyke, S. J. Land, and A. G. Schwartz Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women Carcinogenesis, April 1, 2009; 30(4): 626 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis, P. Brennan, F. Canzian, J. P. A. Ioannidis, G. Matullo, M. Ritchie, U. Stromberg, E. Taioli, and J. Thompson Expectations and challenges stemming from genome-wide association studies Mutagenesis, November 1, 2008; 23(6): 439 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Taioli Gene-environment interaction in tobacco-related cancers Carcinogenesis, August 1, 2008; 29(8): 1467 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Bell, B. W. Brannigan, K. Matsuo, D. M. Finkelstein, R. Sordella, J. Settleman, T. Mitsudomi, and D. A. Haber Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms Clin. Cancer Res., July 1, 2008; 14(13): 4079 - 4084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Sanderson, S. E. Humphries, C. Hubbart, E. Hughes, M. J. Jarvis, and J. Wardle Psychological and Behavioural Impact of Genetic Testing Smokers for Lung Cancer Risk: A Phase II Exploratory Trial J Health Psychol, May 1, 2008; 13(4): 481 - 494. [Abstract] [PDF]
|
|
|
|
|
|
K.-M. Lee, D. Kang, M. L. Clapper, M. Ingelman-Sundberg, M. Ono-Kihara, C. Kiyohara, S. Min, Q. Lan, L. Le Marchand, P. Lin, et al. CYP1A1, GSTM1, and GSTT1 Polymorphisms, Smoking, and Lung Cancer Risk in a Pooled Analysis among Asian Populations Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1120 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hecht, P. W. Villalta, and J.B. Hochalter Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms Carcinogenesis, May 1, 2008; 29(5): 937 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis Am. J. Epidemiol., April 1, 2008; 167(7): 759 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vineis, S. Anttila, S. Benhamou, M. Spinola, A. Hirvonen, C. Kiyohara, S. J. Garte, R. Puntoni, A. Rannug, R. C. Strange, et al. Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis Carcinogenesis, September 1, 2007; 28(9): 1902 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Alberg, J. G. Ford, and J. M. Samet Epidemiology of Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 29S - 55S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Vineis, F Veglia, S Garte, C Malaveille, G Matullo, A Dunning, M Peluso, L Airoldi, K Overvad, O Raaschou-Nielsen, et al. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers Ann. Onc., July 1, 2007; 18(7): 1230 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Schwartz, G. M. Prysak, C. H. Bock, and M. L. Cote The molecular epidemiology of lung cancer Carcinogenesis, March 1, 2007; 28(3): 507 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carlsten and W. Burke Potential for Genetics to Promote Public Health: Genetics Research on Smoking Suggests Caution About Expectations JAMA, November 22, 2006; 296(20): 2480 - 2482. [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hecht, S. G. Carmella, A. Yoder, M. Chen, Z.-z. Li, C. Le, R. Dayton, J. Jensen, and D. K. Hatsukami Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1805 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P A Ioannidis Commentary: Grading the credibility of molecular evidence for complex diseases Int. J. Epidemiol., June 1, 2006; 35(3): 572 - 578. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Yang, J. O. Ebbert, Z. Sun, and R. M. Weinshilboum Role of the Glutathione Metabolic Pathway in Lung Cancer Treatment and Prognosis: A Review J. Clin. Oncol., April 10, 2006; 24(11): 1761 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Larsen, M. L. Colosimo, I. A. Yang, R. Bowman, P. V. Zimmerman, and K. M. Fong CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung Carcinogenesis, March 1, 2006; 27(3): 525 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hecht, M. Chen, A. Yoder, J. Jensen, D. Hatsukami, C. Le, and S. G. Carmella Longitudinal Study of Urinary Phenanthrene Metabolite Ratios: Effect of Smoking on the Diol Epoxide Pathway Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2969 - 2974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. McBride, I. M. Lipkus, D. Jolly, and P. Lyna Interest in Testing for Genetic Susceptibility to Lung Cancer among Black College Students "At Risk" of Becoming Cigarette Smokers Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2978 - 2981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Sanderson and J. Wardle Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers Health Educ Behav, October 1, 2005; 32(5): 640 - 653. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Barnholtz-Sloan, R. Chakraborty, T. A. Sellers, and A. G. Schwartz Examining Population Stratification via Individual Ancestry Estimates versus Self-Reported Race Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1545 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Alberg, M. V. Brock, and J. M. Samet Epidemiology of Lung Cancer: Looking to the Future J. Clin. Oncol., May 10, 2005; 23(14): 3175 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Kelley, E. M. Glaser, J. E. Herndon II, F. Becker, R. Bhagat, Y.-J. Zhang, R. M. Santella, S. G. Carmella, S. S. Hecht, L. Gallot, et al. Safety and Efficacy of Weekly Oral Oltipraz in Chronic Smokers Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 892 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.L. Cote, S.L.R. Kardia, A.S. Wenzlaff, S.J. Land, and A.G. Schwartz Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study Carcinogenesis, April 1, 2005; 26(4): 811 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.S. Wenzlaff, M.L. Cote, C.H. Bock, S.J. Land, and A.G. Schwartz GSTM1, GSTT1 and GSTP1 polymorphisms, environmental tobacco smoke exposure and risk of lung cancer among never smokers: a population-based study Carcinogenesis, February 1, 2005; 26(2): 395 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ntais, A. Polycarpou, and J. P.A. Ioannidis Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms with the Risk of Prostate Cancer: A Meta-analysis Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 176 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Benhamou and A. Sarasin ERCC2 /XPD Gene Polymorphisms and Lung Cancer: A HuGE Review Am. J. Epidemiol., January 1, 2005; 161(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Carmella, M. Chen, H. Yagi, D. M. Jerina, and S. S. Hecht Analysis of Phenanthrols in Human Urine by Gas Chromatography-Mass Spectrometry: Potential Use in Carcinogen Metabolite Phenotyping Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2167 - 2174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Morgenstern Oxidative Stress and Human Genetic Variation J. Nutr., November 1, 2004; 134(11): 3173S - 3174S. [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Alexandrie, F. Nyberg, M. Warholm, and A. Rannug Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 908 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Schwartz Genetic Predisposition to Lung Cancer Chest, May 1, 2004; 125(5_suppl): 86S - 89S. [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hecht, M. Chen, H. Yagi, D. M. Jerina, and S. G. Carmella r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in Human Urine: A Potential Biomarker for Assessing Polycyclic Aromatic Hydrocarbon Metabolic Activation Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1501 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sweeney, V. Nazar-Stewart, P. L. Stapleton, D. L. Eaton, and T. L. Vaughan Glutathione S-transferase M1, T1, and P1 Polymorphisms and Survival among Lung Cancer Patients Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Hung, P. Boffetta, J. Brockmoller, D. Butkiewicz, I. Cascorbi, M. L. Clapper, S. Garte, A. Haugen, A. Hirvonen, S. Anttila, et al. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis Carcinogenesis, May 1, 2003; 24(5): 875 - 882. [Abstract] [Full Text] [PDF]
|
|