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Carcinogenesis Advance Access originally published online on September 11, 2003
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Carcinogenesis, Vol. 24, No. 11, 1855-1857, November 2003
© 2003 Oxford University Press

RESPONSE TO LETTER TO THE EDITOR

Re: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected

J.G. Hengstler

Institute of Legal Medicine and Rudolf Boehm Institute of Pharmacology und Toxicology, Härtelstr. 16-18, D-04107 Leipzig, Germany

The first 150 words of the full text of this article appear below.

Dear Sir,

Thank you very much for giving us the opportunity to reply to the letter of Drs Lison and Kirsch-Volders concerning our article ‘Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected. Carcinogenesis, 2003, 24, 63–73’. We appreciate Drs Lison's and Kirsch-Volder's effort to discuss the relevance of exposure to heavy metals and possible implications for the health of exposed individuals. Concerning the present letter of Drs Lison and Kirsch-Volders we do not agree with their major arguments.

Drs Lison and Kirsch-Volders wrote: ‘The work described by Hengstler et al. combined some exposure biomarkers, but only a single biomarker, ... namely DNA-SSB which detects reversible lesions’.

Our reply: further biomarkers have been studied in the same population. For instance Jung et al., Institute of Occupational Medicine, University of Mainz, determined . . . [Full Text of this Article]


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