Carcinogenesis, Vol. 24, No. 3, 483-489,
March 2003
© 2003 Oxford University Press
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION |
Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
1 USC/Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033-0800,
2 Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709,
3 Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292 and
4 The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
We have previously reported permanent hair dye use to be a significant risk factor for bladder cancer in US women.
We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow acetylators. In the present study, we assessed the possible modifying effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye–bladder cancer association, among female participants (159 cases, 164 controls) of the Los Angeles Bladder Cancer Study. Among NAT2 slow acetylators, exclusive permanent hair dye use was associated with a 2.9-fold increased risk of bladder cancer (95% CI = 1.2–7.5). The corresponding relative risk in NAT2 rapid acetylators was 1.3 (95% CI = 0.6–2.8). Frequency- and duration-related dose–response relationships confined to NAT2 slow acetylators were all positive and statistically significant. No such associations were noted among NAT2 rapid acetylators. Among CYP1A2 ‘slow’ individuals, exclusive permanent hair dye use was associated with a 2.5-fold increased risk of bladder cancer (95% CI = 1.04–6.1). The corresponding risk in CYP1A2 ‘rapid’ individuals was 1.3 (95% CI = 0.6–2.7). Frequency- and duration-related dose–response relationships confined to CYP1A2 ‘slow’ individuals were all positive and statistically significant. No such associations were noted among CYP1A2 ‘rapid’ individuals. Among lifelong non-smoking women, individuals exhibiting the non-NAT1*10 genotype showed a statistically significant increase in bladder cancer risk associated with exclusive permanent hair dye use (OR = 6.8, 95% CI = 1.7–27.4). The comparable OR in individuals with the NAT1*10 genotype was 1.0 (95%CI = 0.2–4.3). Similarly, all frequency- and duration-related dose–response relationships confined to individuals possessing the non-NAT1*10 genotype were positive and statistically significant. On the other hand, individuals of NAT1*10 genotype exhibited no such associations.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Takkouche, C. Regueira-Mendez, and A. Montes-Martinez Risk of cancer among hairdressers and related workers: a meta-analysis Int. J. Epidemiol., September 14, 2009; (2009) dyp283v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sasaki, M. Horikawa, K. Orikasa, M. Sato, Y. Arai, Y. Mitachi, M. Mizugaki, M. Ishikawa, and M. Hiratsuka Possible Relationship Between the Risk of Japanese Bladder Cancer Cases and the CYP4B1 Genotype Jpn. J. Clin. Oncol., September 1, 2008; 38(9): 634 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Yuan, K. K. Chan, G. A. Coetzee, J.E. Castelao, M. A. Watson, D. A. Bell, R. Wang, and M. C. Yu Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer Carcinogenesis, July 1, 2008; 29(7): 1386 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, S. D. Sanjose, P. M. Bracci, L. M. Morton, R. Wang, P. Brennan, P. Hartge, P. Boffetta, N. Becker, M. Maynadie, et al. Personal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma Am. J. Epidemiol., June 1, 2008; 167(11): 1321 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Final Report on the Safety Assessment of 3-Methylamino-4-Nitrophenoxyethanol as Used in Hair Dyes International Journal of Toxicology, March 1, 2008; 27(2_suppl): 41 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Final Report on the Safety Assessment of HC Red No. 7 International Journal of Toxicology, January 1, 2008; 27(1_suppl): 45 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006 International Journal of Toxicology, January 1, 2008; 27(1_suppl): 77 - 142. [Full Text] [PDF]
|
|
|
|
|
|
Y. Zang, M. A. Doll, S. Zhao, J. C. States, and D. W. Hein Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2 Carcinogenesis, August 1, 2007; 28(8): 1665 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Morton, L. Bernstein, S. S. Wang, D. W. Hein, N. Rothman, J. S. Colt, S. Davis, J. R. Cerhan, R. K. Severson, R. Welch, et al. Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma Carcinogenesis, August 1, 2007; 28(8): 1759 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. LIND, S. JOHNSSON, B. MEDING, and A. BOMAN Permeability of Hair Dye Compounds p-Phenylenediamine, Toluene-2,5-Diaminesulfate and Resorcinol through Protective Gloves in Hairdressing Ann. Hyg., July 1, 2007; 51(5): 479 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kellen, M. Hemelt, K. Broberg, K. Golka, V. N. Kristensen, R. J. Hung, G. Matullo, R. D. Mittal, S. Porru, A. Povey, et al. Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review Am. J. Epidemiol., June 1, 2007; 165(11): 1221 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Final Report on the Safety Assessment of Basic Blue 99 International Journal of Toxicology, March 1, 2007; 26(2_suppl): 51 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Final Report on the Safety Assessment of Disperse Blue 7 International Journal of Toxicology, March 1, 2007; 26(2_suppl): 65 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Final Report on the Safety Assessment of HC Yellow No. 5 International Journal of Toxicology, March 1, 2007; 26(2_suppl): 113 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zayas, S. W. Stillwell, J. S. Wishnok, L. J. Trudel, P. Skipper, M. C. Yu, S. R. Tannenbaum, and G. N. Wogan Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients Carcinogenesis, February 1, 2007; 28(2): 342 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Bluhm, S. H. Zahm, H. A. Fine, P. M. Black, J. S. Loeffler, W. R. Shapiro, R. G. Selker, and P. D. Inskip Personal Hair Dye Use and Risks of Glioma, Meningioma, and Acoustic Neuroma among Adults Am. J. Epidemiol., January 1, 2007; 165(1): 63 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lin, C. P. Dinney, H. B. Grossman, and X. Wu Personal permanent hair dye use is not associated with bladder cancer risk: evidence from a case-control study. Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1746 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Annual Review of Cosmetic Ingredient Safety Assessments--2004/2005 International Journal of Toxicology, March 1, 2006; 25(2_suppl): 1 - 89. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Deguchi, S. Yoshida, S. Kennedy, N. Ohara, S. Motoyama, and T. Maruo Lack of Association Between Endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) Polymorphisms in a Japanese Population Reproductive Sciences, April 1, 2005; 12(3): 208 - 213. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Gan, P. L. Skipper, M. Gago-Dominguez, K. Arakawa, R. K. Ross, M. C. Yu, and S. R. Tannenbaum Alkylaniline-Hemoglobin Adducts and Risk of Non-Smoking-Related Bladder Cancer J Natl Cancer Inst, October 6, 2004; 96(19): 1425 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol International Journal of Toxicology, March 1, 2004; 23(2_suppl): 1 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Cortessis, K. Siegmund, S. Xue, R. K. Ross, and M. C. Yu A case-control study of cyclin D1 CCND1 870A->G polymorphism and bladder cancer Carcinogenesis, October 1, 2003; 24(10): 1645 - 1650. [Abstract] [Full Text] [PDF]
|
|