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Carcinogenesis, Vol. 24, No. 4, 625-635, April 2003
© 2003 Oxford University Press

COMMENTARY

Variability and regulation of O6-alkylguanine–DNA alkyltransferase

Geoffrey P. Margison1,, Andrew C. Povey2, Bernd Kaina3 and Mauro F. Santibáñez Koref4

1 Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK
2 Centre for Occupational and Environmental Health, University of Manchester, Manchester M13 9PL, UK
3 Institute of Toxicology, Division of Applied Toxicology, University of Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany
4 Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, Berlin 13 092, Germany

To whom correspondence should be addressed Email: gmargison{at}picr.man.ac.uk

O6-Alkylguanine–DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.


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