Carcinogenesis Advance Access originally published online on March 28, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Carcinogenesis, Vol. 24, No. 5, 899-904,
May 2003
© 2003 Oxford University Press
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION |
A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2–3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55
1 Institute of Human Genetics, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark
2 National Institute of Occupational Health, DK-2100 Copenhagen O, Denmark
3 Institute of Epidemiology, The Danish Cancer Society, DK-2100 Copenhagen, Denmark
4 Department of Clinical Epidemiology, Aalborg Hospital and Aarhus University Hospital and Department of Epidemiology and Social Medicine, University of Aarhus, DK-8000 Aarhus C, Denmark
5 To whom correspondence should be addressed Email: nexo{at}humgen.au.dk
The new genetic information, in particular the greatly increased density of markers in the chromosomal maps, may permit analysis of the importance of genes in the development of disease exclusively from molecular epidemiological studies. Motivated by our previous results on the same region in relation to basal cell carcinoma we have investigated the occurrence of post-menopausal breast cancer in relation to a number of single nucleotide polymorphisms in the chromosomal region 19q13.2–3. A case–control study including 425 human cases and a similar number of controls was nested in a population-based prospective investigation encompassing 24 697 Danish post-menopausal women (aged 50–64 at inclusion) living in Copenhagen or Aarhus. We combined three markers located together in or near the gene RAI into a high-risk haplotype. Compared with all other haplotypes, those who were homozygous had a rate ratio of 1.64 (95% CI 1.17–2.29, P 
0.004) for development of breast cancer. When we further focused on those persons with post-menopausal breast cancer before age 55 the rate ratio increased to 9.5 (95% CI 2.21–40.79, P 0.003). The likely explanation for our results is a common recessive genetic variant located in or near the gene RAI, which, when homozygous, conveys an increased risk of breast cancer. Presumably it is identical to the genetic variant previously observed in the same region that increases the risk of basal cell carcinoma before age 50.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Vangsted, T. W. Klausen, P. Gimsing, N. F. Andersen, N. Abildgaard, H. Gregersen, and U. Vogel A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support Haematologica, September 1, 2009; 94(9): 1274 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yin, U. Vogel, Y. Ma, R. Qi, and H. Wang HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population Carcinogenesis, July 1, 2009; 30(7): 1181 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Vogel, J. Christensen, B. A Nexo, H. Wallin, S. Friis, and A. Tjonneland Peroxisome profilerator-activated receptor{gamma}2 Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes Carcinogenesis, February 1, 2007; 28(2): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matullo, A.M. Dunning, S. Guarrera, C. Baynes, S. Polidoro, S. Garte, H. Autrup, C. Malaveille, M. Peluso, L. Airoldi, et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study Carcinogenesis, May 1, 2006; 27(5): 997 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Matullo, S. Guarrera, C. Sacerdote, S. Polidoro, L. Davico, S. Gamberini, M. Karagas, G. Casetta, L. Rolle, A. Piazza, et al. Polymorphisms/Haplotypes in DNA Repair Genes and Smoking: A Bladder Cancer Case-Control Study Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Vogel, A. Olsen, H. Wallin, K. Overvad, A. Tjonneland, and B. A. Nexo No Association between OGG1 Ser326Cys and Risk of Basal Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., October 1, 2004; 13(10): 1680 - 1681. [Full Text] [PDF]
|
|