Carcinogenesis Advance Access originally published online on November 6, 2003
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Carcinogenesis, Vol. 25, No. 2, 229-235,
February 2004
© Oxford University Press; all rights reserved
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION |
Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer
1 Genome Analysis Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France, 2 Department of Science for the Study of Man and Environment, University of Pisa, Pisa, Italy and 3 Department of Toxicology, National Institute of Occupational Health, PO Box 8149 Dep., 0033 Oslo, Norway
Studies have indicated that inflammation, in conjunction with the production of reactive oxygen species, may play a key role in lung cancer development. In this study, 250 lung cancer patients and 214 controls were genotyped for polymorphisms of the inflammation-related genes prostaglandin synthase-2/cyclooxygenase-2 (COX2/PTGS2), interleukin-6 (IL6), interleukin-8 (IL8) and peroxisome proliferator-activated receptor 
(PPARg). We found that carriers of the C allele of a polymorphism in the 3'-UTR of COX2 had a significantly increased risk of lung cancer, with odds ratios of 4.28 (95% CI, 2.44–7.49) for homozygotes and 2.12 (95% CI, 1.25–3.59) for heterozygotes. Additionally, we found that an IL8 promoter polymorphism had a protective effect for lung cancer in female subjects, whereas an IL6 promoter polymorphism was only associated with risk of squamous cell carcinoma. This is the first study implicating polymorphisms in inflammatory genes in the risk of lung cancer.
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