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Carcinogenesis Advance Access originally published online on July 13, 2005
Carcinogenesis 2005 26(12):2213; doi:10.1093/carcin/bgi181
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Carcinogenesis vol.26 no.12 © Oxford University Press 2005; all rights reserved.

LETTER TO THE EDITOR

Reply: a bias in genotyping of the ERBB2 (HER2) Ile655Val variant

Patrick R. Benusiglio *, Craig Luccarini, Oluseun Ajai, Bruce A.J. Ponder and Paul D. Pharoah

Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK

* To whom correspondence should be addressed. Email: pbenusiglio@yahoo.com

The first 10% of the full text of this article appears below.

Dear Sir,

In a recent study of the neighbouring ERBB2 single nucleotide polymorphisms (SNPs) Ile654Val and Ile655Val, Frank et al. concluded that TaqMan genotyping of Ile655Val provided inaccurate results (1). In their assay, a valine at position 654 interfered with the correct binding of . . . [Full Text of this Article]


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