Skip Navigation


Carcinogenesis Advance Access originally published online on November 25, 2004
Carcinogenesis 2005 26(3):579-585; doi:10.1093/carcin/bgh343
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
26/3/579    most recent
bgh343v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gong, Z.
Right arrow Articles by Hebert, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gong, Z.
Right arrow Articles by Hebert, J. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis vol.26 no.3 © Oxford University Press 2004; all rights reserved.

ARTICLE

The PPAR{gamma} Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas

Zhihong Gong1,2, Dawen Xie1,2,6, Zonglin Deng1,2, Roberd M. Bostick3, Stephanie J. Muga2,4, Thomas G. Hurley1,2 and James R. Hebert1,2,5

1 Department of Epidemiology and Biostatistics, University of South Carolina, Arnold School of Public Health, Columbia, SC, USA, 2 South Carolina Cancer Center, Columbia, SC, USA, 3 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA, 4 Department of Pathology, University of South Carolina School of Medicine, Columbia, SC, USA and 5 Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA

6 To whom correspondence should addressed at: University of South Carolina, 14 Richland Medical Park, Suite 500, Columbia, SC 29203, USA. Tel: +1 803 434 3707; Fax: +1 803 434 3795; Email: dawen.xie{at}palmettohealth.org

Peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}), a member of the nuclear hormone receptor superfamily initially shown to be a key regulator of fat cell differentiation, can inhibit cell growth and induce apoptosis in colon cell lines. There are heterozygous loss of function mutations in the gene encoding PPAR{gamma} in tumors from ~10% of human colon cancer patients. A common structural polymorphism has been detected in the PPAR{gamma} gene at codon 12 (Pro12Ala). We investigated the hypothesis that the PPAR{gamma} Pro12Ala polymorphism is associated with colorectal adenoma risk in a recently concluded case–control study of incident sporadic colorectal adenomas (163 cases and 212 controls). The multivariate-adjusted odds ratio (OR) for incident sporadic colorectal adenoma was 0.65 (95% CI 0.39–1.09) for those with the Pro12Ala or Ala12Ala genotype compared with those with the Pro12Pro genotype. Multivariate-adjusted inverse associations with the Ala12 variant were more pronounced among those who were female (OR 0.36, 95% CI 0.18–0.75) or did not take non-steroidal anti-inflammatory drugs (OR 0.38, 95% CI 0.14–1.00). Marginally significant results were observed among those with a lower waist:hip ratio (OR 0.52, 95% CI 0.24–1.12) or a lower body mass index (OR 0.46, 95% 0.20–1.05). Smoking was a very strong risk factor (OR 2.34, 95%CI 1.37–4.02) for colorectal adenoma among those with the wild-type (Pro12Ala) genotype, but not those with the Ala12 variant (OR 0.86, 95%CI 0.35–2.09). Larger studies are needed to validate these results, which suggest that the PPAR{gamma} Pro12Ala polymorphism may interact with other factors to protect against colorectal adenoma.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
K. N. Prasad, A. Saxena, U. C. Ghoshal, M. R. Bhagat, and N. Krishnani
Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease
Ann. Onc., July 1, 2008; 19(7): 1299 - 1303.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S.-C. Chang, A. Rashid, Y.-T. Gao, G. Andreotti, M.-C. Shen, B.-S. Wang, T.-Q. Han, B.-H. Zhang, L. C. Sakoda, M. F. Leitzmann, et al.
Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
Carcinogenesis, May 1, 2008; 29(5): 944 - 948.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
W.-P. Koh, J.-M. Yuan, D. Van Den Berg, S. A. Ingles, and M. C. Yu
Peroxisome proliferator-activated receptor (PPAR) {gamma} gene polymorphisms and colorectal cancer risk among Chinese in Singapore
Carcinogenesis, September 1, 2006; 27(9): 1797 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. J. Gunter, F. Canzian, S. Landi, S. J. Chanock, R. Sinha, and N. Rothman
Inflammation-related gene polymorphisms and colorectal adenoma.
Cancer Epidemiol. Biomarkers Prev., June 1, 2006; 15(6): 1126 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
A. Huber, E.-K. Bentz, C. Schneeberger, J. C. Huber, L. Hefler, and C. Tempfer
Ten Polymorphisms of Estrogen-Metabolizing Genes and a Family History of Colon Cancer--An Association Study of Multiple Gene-Gene Interactions
Reproductive Sciences, October 1, 2005; 12(7): e51 - e54.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.