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Carcinogenesis Advance Access originally published online on June 1, 2005
Carcinogenesis 2005 26(9):1488-1492; doi:10.1093/carcin/bgi148
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Carcinogenesis vol.26 no.9 © Oxford University Press 2005; all rights reserved.

COMMENTARY

Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new

Stephen S. Hecht

The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street, SE, Minneapolis, MN 55455, USA

Tel: +1 612 624 7604; Fax: +1 612 626 5135; Email: hecht002{at}umn.edu

A new study demonstrates that lifetime whole-body exposure of B6C3F1 mice to high doses of cigarette smoke robustly increases lung cancer incidence compared with sham exposed animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on lung cancer in an animal model. This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations and possible applications of available models.


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