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Carcinogenesis Advance Access originally published online on October 11, 2005
Carcinogenesis 2006 27(1):23-31; doi:10.1093/carcin/bgi243
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Carcinogenesis vol.27 no.1 © Oxford University Press 2005; all rights reserved.

REVIEW

Emerging role of KLF4 in human gastrointestinal cancer

Daoyan Wei 1, Masashi Kanai 1, Suyun Huang 2, 3 and Keping Xie 1, 3, *

1 Department of Gastrointestinal Medical Oncology, 2 Department of Neurosurgery and 3 Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA

* To whom correspondence should be addressed. Tel: +1 713 792 2013; Fax: +1 713 745 1163; Email: kepxie{at}mail.mdanderson.org

Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.


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