Skip Navigation


Carcinogenesis Advance Access originally published online on January 16, 2006
Carcinogenesis 2006 27(6):1128-1133; doi:10.1093/carcin/bgi342
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
27/6/1128    most recent
bgi342v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Alija, A.J.
Right arrow Articles by Eckl, P.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alija, A.J.
Right arrow Articles by Eckl, P.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ß-Carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes

A.J. Alija, N. Bresgen, O. Sommerburg 1, C.D. Langhans 2, W. Siems 3 and P.M. Eckl *

Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria 1 Children's Hospital, University of Ulm, Germany 2 Children's Hospital, University of Heidelberg, Germany and 3 Herzog-Julius Hospital for Rheumatology and Orthopedics, Kurhausstrasse 13-17, D-38667 Bad Harzburg, Germany

* To whom correspondence should be addressed. Tel: +43 662 8044 5782; Fax: +43 662 8044 144; Email: peter.eckl{at}sbg.ac.at

Since it has to be expected that individuals exposed to oxidative stress who take supplements of ß-carotene are simultaneously exposed to both ß-carotene cleavage products (CPs) and oxidative stress, and both exposures have been demonstrated to cause genotoxic effects in primary rat hepatocytes, cyto- and genotoxic effects on primary rat hepatocytes after supplementation of the medium with increasing concentrations of a CP mixture during exposure to oxidative stress by treatment with either DMNQ (2,3-dimethoxy-1,4-naphthoquinone) or hypoxia/reoxygenation (Hy/Reox) was investigated. The cytological endpoints analysed were the mitotic indices, the percentages of apoptotic and necrotic cells, the percentages of micronucleated (MN) cells and the number of chromosomal aberrations (CAs) and sister chromatid exchanges (SCE). The results obtained clearly demonstrate that the CP mixture enhances the genotoxic effects of oxidative stress exposure, whereas it had no effect at all on the endpoints of cytotoxicity studied. These results further support the hypothesis that CP might be responsible for the reported carcinogenic response in the beta-CArotene and Retinol Efficacy Trial (CARET) and Alpha-Tocopherol Beta-carotene Cancer prevention (ATBC) chemoprevention trials.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S. T. Dance-Barnes, N. D. Kock, J. E. Moore, E. Y. Lin, L. J. Mosley, R. B. D'Agostino Jr, T. P. McCoy, A. J. Townsend, and M. S. Miller
Lung tumor promotion by curcumin
Carcinogenesis, June 1, 2009; 30(6): 1016 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
L Alpsoy, G Agar, and M Ikbal
Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes
Toxicology and Industrial Health, April 1, 2009; 25(3): 183 - 188.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Sergeant, J.-J. Li, C. Fox, N. Brookbank, D. Rea, T. D. H. Bugg, and A. J. Thompson
Selective Inhibition of Carotenoid Cleavage Dioxygenases: PHENOTYPIC EFFECTS ON SHOOT BRANCHING
J. Biol. Chem., February 20, 2009; 284(8): 5257 - 5264.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.