Carcinogenesis Advance Access originally published online on July 7, 2007
Carcinogenesis 2007 28(9):1960-1964; doi:10.1093/carcin/bgm151
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
1 International Agency for Research on Cancer, Lyon 69008, France
2 University of California, School of Public Health, Berkeley, CA 94720, USA
3 Institute of Carcinogenesis, Cancer Research Centre, Moscow 115478, Russia
4 Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc 77515, Czech Republic
5 Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague 12800, Czech Republic
6 Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65200, Czech Republic
7 Department of Epidemiology, Institute of Occupational Medicine, Lodz 90–950, Poland
8 Institute of Public Health, Bucharest 76256, Romania
9 Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Gaithersburg, MD 20877, USA
* To whom correspondence should be addressed. Tel: +301 496 6427; Fax: +301 402 1819; Email: moorele{at}mail.nih.gov
High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion. Modification of this relationship by host genetic factors is unknown. We investigated cruciferous vegetable intake in 1097 cases and 1555 controls enrolled in a multicentric case–control study from the Czech Republic, Poland, Romania and Russia. To assess possible gene–diet interactions, genotyped cases (N = 925) and controls (N = 1247) for selected functional or non-synonymous polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution. The odds ratio (OR) for low (less than once per month) versus high (at least once per week) intake of cruciferous vegetables was 1.29 [95% confidence interval (CI): 1.02–1.62; P-trend = 0.03]. When low intake of cruciferous vegetables (less than once per month) was stratified by GST genotype, higher kidney cancer risks were observed among individuals with the GSTT1 null (OR = 1.86; 95% CI: 1.07–3.23; P-interaction = 0.05) or with both GSTM1/T1 null genotypes (OR = 2.49; 95% CI: 1.08–5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms.
Abbreviations: CI, confidence interval; GST, glutathione S-transferase; ITC, isothiocyanate; OR, odds ratios; RCC, renal cell carcinoma
Received February 26, 2007; revised May 22, 2007; accepted June 26, 2007.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. E. Moore, P. Brennan, S. Karami, I. Menashe, S. I. Berndt, L. M. Dong, A. Meisner, M. Yeager, S. Chanock, J. Colt, et al. Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk Cancer Res., October 15, 2009; 69(20): 8001 - 8008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Karami, P. Boffetta, N. Rothman, R. J. Hung, T. Stewart, D. Zaridze, M. Navritalova, D. Mates, V. Janout, H. Kollarova, et al. Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms Carcinogenesis, August 1, 2008; 29(8): 1567 - 1571. [Abstract] [Full Text] [PDF]
|
|