Skip Navigation


Carcinogenesis Advance Access originally published online on July 5, 2007
Carcinogenesis 2007 28(9):1965-1970; doi:10.1093/carcin/bgm155
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
28/9/1965    most recent
bgm155v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Google Scholar
Right arrow Articles by Berndt, S. I.
Right arrow Articles by Hayes, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berndt, S. I.
Right arrow Articles by Hayes, R. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2007.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma

Sonja I. Berndt1,*, Wen-Yi Huang1, Nilanjan Chatterjee1, Meredith Yeager1,2, Robert Welch1,2, Stephen J. Chanock1, Joel L. Weissfeld3, Robert E. Schoen3,4 and Richard B. Hayes1

1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
2 SAIC-Frederick, NCI-FCRDC, Frederick, MD 20877, USA
3 Department of Epidemiology and the University of Pittsburgh Cancer Institute
4 Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA

* To whom correspondence should be addressed. Tel: +301 594 7898; Fax: +301 402 1819; Email: berndts{at}mail.nih.gov

Transforming growth factor beta 1 (TGFB1) is a multifunctional cytokine that has been implicated in the pathogenesis of colorectal neoplasia. To investigate the association between genetic variants in TGFB1 and the risk of colorectal adenoma, we conducted a case–control study of 754 advanced adenoma cases and 769 controls from the baseline screening exam of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cases included participants diagnosed with advanced left-sided adenoma (≥1 cm, high-grade dysplasia or villous characteristics), and controls were subjects without evidence of a left-sided polyp by sigmoidoscopy. DNA was extracted from blood specimens, and five single-nucleotide polymorphisms in TGFB1 of known or suggested functional significance (–800G>A, –509C>T, Leu10Pro, Arg25Pro and Thr263Ile) were genotyped. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between each polymorphism and adenoma. The high TGFB1 producer genotypes, –509TT and 10Pro/Pro, were associated with an increased risk of colorectal adenoma compared with other genotypes (OR = 1.51, 95% CI: 1.04–2.20 and OR = 1.37, 95% CI: 1.02–1.86, respectively). These increased risks, particularly for –509TT, were greater for persons with multiple adenomas (OR = 1.89, 95% CI: 1.16–3.09, P = 0.01) and individuals with rectal adenoma (OR = 2.95, 95% CI: 1.66–5.26, P = 0.0002). Haplotype analysis revealed similar findings under a recessive model. No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma.

Abbreviations: 95% CI, 95% confidence interval; OR, odds ratio; TGFB1, transforming growth factor beta 1; TGFBRII, transforming growth factor beta receptor type II

Received April 30, 2007; revised June 13, 2007; accepted June 26, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
B. S. Saltzman, J. F. Yamamoto, R. Decker, L. Yokochi, A. G. Theriault, T. M. Vogt, and L. Le Marchand
Association of Genetic Variation in the Transforming Growth Factor {beta}-1 Gene with Serum Levels and Risk of Colorectal Neoplasia
Cancer Res., February 15, 2008; 68(4): 1236 - 1244.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.