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Carcinogenesis Advance Access originally published online on February 28, 2008
Carcinogenesis 2008 29(9):1825-1830; doi:10.1093/carcin/bgn038
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis

Andrea Bilger1, Ruth Sullivan2, Amy J. Prunuske1,4, Linda Clipson1, Norman R. Drinkwater1 and William F. Dove1,3,*

1 McArdle Laboratory for Cancer Research, Department of Oncology
2 Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
3 Laboratory of Genetics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
4 Present address: Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA

* To whom correspondence should be addressed. Tel: +1 608 262 4977; Fax: +1 608 262 2824; Email: dove{at}oncology.wisc.edu

Using a mouse predisposed to neoplasia by a germ line mutation in Apc (ApcMin), we tested whether induced hyperplasia is sufficient to increase intestinal tumor multiplicity or size in the intestine. We found that hyperplasia in the jejunum correlated with a significant increase in tumor multiplicity. However, tumor multiplicity was unchanged in the hyperplastic colon. This result indicates that even an intestine predisposed to neoplasia can, in certain regions including the colon, accommodate net increased cell growth without developing more neoplasms. Where hyperplasia correlated with increased tumor multiplicity, it did not increase the size or net growth of established tumors. This result suggests that the event linking hyperplasia and neoplasia in the jejunum is tumor establishment. Two novel observations arose in our study: the multiple intestinal neoplasia (Min) mutation partially suppressed both mitosis and transforming growth factor alpha-induced hyperplasia throughout the intestine; and zinc treatment alone increased tumor multiplicity in the duodenum of Min mice.

Abbreviations: EGFR, epidermal growth factor receptor; H&E, hematoxylin and eosin; Min, multiple intestinal neoplasia; TGF{alpha}, transforming growth factor alpha; Tg(MT-TGFa), Tg(Mt-1,rTgfa)Bril49

Received August 30, 2007; revised January 11, 2008; accepted January 29, 2008.


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