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© 1985 Oxford University Press

other

Mutagenicity of nitrofluoranthenes, 3-aminofluoranthene and 1-nitropyrene in Chinese hamster V79 cells

David L. Berry 1 3, Gary M. Schoofs 1 and William A. Vance 2

1United States Department of Agriculture, Western Regional Research Center, Toxicology and Biological Research Evaluation Unit Berkeley, CA 94710
2Air and Industrial Hygiene Laboratory, California State Department of Health 2151 Berkeley Way, Berkeley, CA 94704, USA

3To whom reprint requests should be sent

1-Nitropyrene (1-NO2Py), 3-nitrofluoranthene (3-NO2Ft), 3-aminofluoranthene (3-NH2Ft) and 8-nitrofluoranthene (8-NO2Ft) were tested for mutagenicity in cultured Chinese hamster V79 cells. Mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) gene locus were quantified. 1-NO2Py had marginal direct-acting mutagenicity which was enhanced by a mixture of Aroclor 1254- and 1242-induced liver homogenates (S9) in the treatment medium. 1-NO2Py was more mutagenic with S9 activation than 3-NO2Ft, 3-NH2Ft or 8-NO2Ft. However, 8-NO2Ft, 3-NO2Ft and 3-NH2Ft were more mutagenic than 1-NO2Py when a post-microsomal liver supernatant (S100) was used for metabolic activation. The results of these investigations strongly support activation of some nitrated polycyclic aromatic hydrocarbons to proximate mutagens by a sequence of reductions and possible formation of polycyclic aromatic hydroxylamines.


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