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© 1985 Oxford University Press

other

c-Ha-ras not c-Ki-ras activation in three colon tumour cell lines

D.A. Greenhalgh and A.R. Kinsella 1

Paterson Laboratories, Christie Hospital and Holt Radium Institute Manchester M20 9BX, UK

1To whom reprint requests should be sent

Using the NIH 3T3 transformation assay system, an activated c-Ha-ras transforming gene has been identified in three distinct early passage colon carcinoma cell lines isolated from an invasive, differentiated, adenocarcinoma. The p21 c-Ha-ras gene product from these cell lines displayed an altered electrophorectic mobility and a point mutation in the DNA coding sequence leading to an amino acid substitution at position 12.


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[Abstract] [PDF]


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