Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gschwendt, M.
Right arrow Articles by Marks, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gschwendt, M.
Right arrow Articles by Marks, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 Oxford University Press

research-article

Cyclosporin A inhibits phorbol ester-induced cellular proliferation and tumor promotion as well as phosphorylation of a 100-kd protein in mouse epidermis

Michael Gschwendt, Walter Kittstein and Friedrich Marks

Deutsches Krebsforschungszentrum (German Cancer Research Center), Institut f¨r Biochemie, Im Neuenheimer Feld 280, 0-6900 Heidelberg, FRG

Mouse epidermis and HEL30 keratinocytes contain cellular binding sites for the immunosuppressive agent cyclosporin A (CsA). Phorbol ester-induced DNA synthesis and tumor promotion in mouse skin is strongly suppressed by CsA. The anti-tumor effect of CsA is not the consequence of destruction of initiated cells. CsA selectively inhibits the phosphorylation in vitro of a protein with the relative molecular mass of 100 kd in mouse epidermis and HEL30 cytosol. The CsA-suppressible phosphorylation in vitro does not depend on the addition of Ca2+, phosphoilpid and the phorbol ester TPA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.