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© 1987 Oxford University Press

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Resistance of 7, 12-dimethylbez[a]anthracene — deoxyadenosine adducts in DNA to hydrolysis by snake venom phosphodiesterase

Anthony Dipple and Margaret A. Pigott

BRI-Basic Research Program, Laboratory of Chemical and Physical Carcmogenesis NCI-Frederick Cancer Research Facility, Frederick, MD 21701, USA

In enzymatic hydrolyses of 7,12-dimethylbenz[a]anthracene (DMBA)-modified DNA isolated from fetal mouse cell cultures, a low concentration of venom phosphodiesterase was sufficient for complete release of DMBA-deoxyguanosine ad-ducts. However, efficient release of DMBA-deoxyadenosine adducts required much higher levels of phosphodiesterase. if these adducts exhibit similarly differential susceptibilities to exonucleases involved in DNA metabolism or repair, each adduct could result in significantly different biological effects in vivo.


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