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Carcinogenesis Advance Access published online on March 28, 2003
Carcinogenesis, doi:10.1093/carcin/bgg039
© 2003 by Oxford University Press
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© 2003 Oxford University Press

REVIEW

Tissue factor signal transduction in angiogenesis

Henri H. Versteeg 1, Maikel P. Peppelenbosch 1, C. Arnold Spek 1*

1 Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. E-mail: c.a.spek{at}amc.uva.nl.

Received 28 January 2003 ; accepted 26 February 2003

Abstract

Tissue factor, a 47-kD transmembrane glycoprotein, is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process. Although originally identified as a component of the coagulation cascade, it has become clear that tissue factor functions as a cytokine-like receptor and this notion was confirmed by the discovery of coagulation-independent actions of tissue factor (which include regulation of tumour growth, embryonic and oncogenic blood vessel formation as well as regulation of inflammation and sepsis). In accordance, tissue factor-mediated signal transduction events are readily detected and the elucidation of the underlying molecular mechanisms has recently seen spectacular progress and it is now understood that the role of tissue factor in angiogenesis is both coagulation-dependent and independent. The recent evidence for this emerging insight will be the subject of this review.


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