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Carcinogenesis Advance Access published online on March 28, 2003
Carcinogenesis, doi:10.1093/carcin/bgg041
© 2003 by Oxford University Press
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© 2003 Oxford University Press

COMMENTARY

Precancerous lesions for colorectal cancers in rodents: a new concept

Yasuhiro Yamada 1 Hideki Mori 1*

1 Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan

* Corresponding author. E-mail: hidmori{at}cc.gifu-u.ac.jp.

Received 16 February 2003 ; accepted 3 March 2003

Abstract

It is widely believed that colorectal carcinogenesis is a representative multistep tumorigenesis with events of genetic alterations. Aberrant crypt foci (ACF) recognized in the surface of cancer-predisposed colons of rodents have been regarded as early-appearing preneoplastic lesions. However, it is not clear that such lesions are truly precancerous lesions for colorectal cancers in rodents. Recently, {beta}-catenin-accumulated crypts (BCAC) were identified in colonic mucosa at the early stages of colon carcinogenesis. Accumulating evidences indicate that they are independent small dysplastic lesions of ACF. Here is discussed for the importance of BCAC as precancerous lesions in the colon carcinogenesis.

Colon carcinogenesis, Multistep carcinogenesis, Premalignant lesion, {beta}-Catenin, Rodent
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