Carcinogenesis Advance Access published online on April 11, 2003
Carcinogenesis, doi:10.1093/carcin/bgg059
© 2003 by Oxford University Press
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
1 USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
* Corresponding author. E-mail: ingles{at}usc.edu.
Received 2 January 2003
; revised 18 March 2003
; accepted 30 March 2003
Vitamin D has been implicated as a protective agent against colorectal cancer. We hypothesized that a functional start codon polymorphism in the vitamin D receptor (VDR) influences risk of colorectal carcinoma. We conducted a case-control study nested within a large cohort of Singapore Chinese. VDR genotypes, determined by FokI restriction endonuclease digestion of PCR amplified DNA, were performed on 217 colorectal cancer cases and 890 controls. We found that compared to individuals carrying the FF genotype, those with Ff genotype had a 51% increase in risk of colorectal cancer and those with the ff genotype, an approximate 84% increase in risk (p for trend=0.01). The effect of the VDR genotype on risk appeared to be modified by both dietary calcium and fat. Among those with either low calcium or low fat intake (below the median values in controls), the risk for colorectal cancer increased in a gene-dose dependent manner such that individuals possessing the ff genotype displayed an approximate 2.5-fold increased risk that was statistically significant. There was little evidence of a VDR genotype-colorectal cancer association among subjects with higher than median values of either dietary fat or calcium.
VDR gene, vitamin D, colorectal cancer, polymorphism, calcium, fats
Vitamin D receptor start codon polymorphism and colorectal cancer risk: effect modification by dietary calcium and fat in Singapore Chinese
2 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore 119075
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Jenab, J. McKay, H. B. Bueno-de-Mesquita, F. J.B. van Duijnhoven, P. Ferrari, N. Slimani, E. H.J.M. Jansen, T. Pischon, S. Rinaldi, A. Tjonneland, et al. Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2485 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Ochs-Balcom, M. S. Cicek, C. L. Thompson, T. C. Tucker, R. C. Elston, S. J.Plummer, G. Casey, and L. Li Association of vitamin D receptor gene variants, adiposity and colon cancer Carcinogenesis, September 1, 2008; 29(9): 1788 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D Davis Vitamin D and cancer: current dilemmas and future research needs Am. J. Clinical Nutrition, August 1, 2008; 88(2): 565S - 569S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Slattery, J. Herrick, R. K. Wolff, B. J. Caan, J. D. Potter, and C. Sweeney CDX2 VDR Polymorphism and Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2752 - 2755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Kim and J. A. Milner Dietary Modulation of Colon Cancer Risk J. Nutr., November 1, 2007; 137(11): 2576S - 2579S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sweeney, K. Curtin, M. A. Murtaugh, B. J. Caan, J. D. Potter, and M. L. Slattery Haplotype analysis of common vitamin d receptor variants and colon and rectal cancers. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 744 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Giovannucci Commentary: Vitamin D and colorectal cancer--twenty-five years later Int. J. Epidemiol., April 1, 2006; 35(2): 222 - 224. [Full Text] [PDF]
|
|
|
|
|
|
C. Sweeney, M. A. Murtaugh, K. B. Baumgartner, T. Byers, A. R. Giuliano, J. S. Herrick, R. Wolff, B. J. Caan, and M. L. Slattery Insulin-Like Growth Factor Pathway Polymorphisms Associated with Body Size in Hispanic and Non-Hispanic White Women Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1802 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Adachi, Y. Honma, H. Masuno, K. Kawana, I. Shimomura, S. Yamada, and M. Makishima Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative J. Lipid Res., January 1, 2005; 46(1): 46 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Poon, C. Laprise, M. Lemire, A. Montpetit, D. Sinnett, E. Schurr, and T. J. Hudson Association of Vitamin D Receptor Genetic Variants with Susceptibility to Asthma and Atopy Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 967 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Kemp, C. Thirlwell, O. Sieber, A. Silver, and I. Tomlinson An update on the genetics of colorectal cancer Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R177 - R185. [Abstract] [Full Text] [PDF]
|
|