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Carcinogenesis Advance Access published online on August 1, 2003
Carcinogenesis, doi:10.1093/carcin/bgg128
© 2003 by Oxford University Press
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© 2003 Oxford University Press

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

A case-control study of cyclin D1 CCND1 870A>G polymorphism and bladder cancer

Victoria Cortessis 1*, Kimberly Siegmund 1, Shanyan Xue 1, Ronald K. Ross 1, and Mimi C. Yu 1

1 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

* Corresponding author. E-mail: cortessi{at}usc.edu.

Received 7 January 2003 ; revised 18 July 2003 ; accepted 23 July 2003

Abstract

Expression of cyclin D1 is believed to lead to progression through the G1-S cell cycle checkpoint, and both experimental and pathological evidence suggest that over-expression of this protein may increase the risk of several cancers, including transition cell carcinoma of the bladder. Two major transcripts have been described for CCND1, the gene encoding cyclin D1. CCND1 870A>G, a common single nucleotide polymorphism in the splice donor region of exon 4, may modulate expression of these transcripts, with the A variant resulting in an increased pool of the isozyme encoded by transcript form b. A statistically significant 1.8-fold increased risk for bladder cancer among individuals possessing the A/A genotype was recently reported in a hospital-based case-control study conducted among native Japanese. We conducted a population-based case-control study of incident bladder cancer among non-Hispanic whites in Los Angeles County to examine the relationship between CCND1 870A>G genotypes and bladder cancer risk. No association between the A/A genotype and risk was observed (OR=0.90, 95% confidence interval 0.60-1.33). The null association was not appreciably modified by bladder cancer risk factors, including lifetime smoking history, or by histopathologic classification.

Cyclin D1, CCND1 870A>G, bladder cancer
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